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Shape-memory responses compared between random and aligned electrospun fibrous mats
Significant progress has been made in the design of smart fibers toward achieving improved efficacy in tissue regeneration. While electrospun fibers can be engineered with shape memory capability, both the fiber structure and applied shape-programming parameters are the determinants of final perform...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909598/ https://www.ncbi.nlm.nih.gov/pubmed/36777255 http://dx.doi.org/10.3389/fbioe.2023.1130315 |
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author | Wang, Xianliu Zhang, Zhaowenbin Qin, Chunping Guo, Xuran Zhang, Yanzhong |
author_facet | Wang, Xianliu Zhang, Zhaowenbin Qin, Chunping Guo, Xuran Zhang, Yanzhong |
author_sort | Wang, Xianliu |
collection | PubMed |
description | Significant progress has been made in the design of smart fibers toward achieving improved efficacy in tissue regeneration. While electrospun fibers can be engineered with shape memory capability, both the fiber structure and applied shape-programming parameters are the determinants of final performance in applications. Herein, we report a comparison study on the shape memory responses compared between electrospun random and aligned fibers by varying the programming temperature T ( prog ) and the deforming strain ε ( deform ). A PLLA–PHBV (6:4 mass ratio) polymer blend was first electrospun into random and aligned fibrous mat forms; thereafter, the effects of applying specific T ( prog ) (37°C and 46°C) and ε ( deform ) (30%, 50%, and 100%) on the morphological change, shape recovery efficiency, and switching temperature T ( sw ) of the two types of fibrous structures were examined under stress-free condition, while the maximum recovery stress σ (max) was determined under constrained recovery condition. It was identified that the applied T ( prog ) had less impact on fiber morphology, but increasing ε ( deform ) gave rise to attenuation in fiber diameters and bettering in fiber orientation, especially for random fibers. The efficiency of shape recovery was found to correlate with both the applied T ( prog ) and ε ( deform ), with the aligned fibers exhibiting relatively higher recovery ability than the random counterpart. Moreover, T ( sw ) was found to be close to T ( prog ), thereby revealing a temperature memory effect in the PLLA–PHBV fibers, with the aligned fibers showing more proximity, while the σ (max) generated was ε ( deform )-dependent and 2.1–3.4 folds stronger for the aligned one in comparison with the random counterpart. Overall, the aligned fibers generally demonstrated better shape memory properties, which can be attributed to the macroscopic structural orderliness and increased molecular orientation and crystallinity imparted during the shape-programming process. Finally, the feasibility of using the shape memory effect to enable a mechanoactive fibrous substrate for regulating osteogenic differentiation of stem cells was demonstrated with the use of aligned fibers. |
format | Online Article Text |
id | pubmed-9909598 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99095982023-02-10 Shape-memory responses compared between random and aligned electrospun fibrous mats Wang, Xianliu Zhang, Zhaowenbin Qin, Chunping Guo, Xuran Zhang, Yanzhong Front Bioeng Biotechnol Bioengineering and Biotechnology Significant progress has been made in the design of smart fibers toward achieving improved efficacy in tissue regeneration. While electrospun fibers can be engineered with shape memory capability, both the fiber structure and applied shape-programming parameters are the determinants of final performance in applications. Herein, we report a comparison study on the shape memory responses compared between electrospun random and aligned fibers by varying the programming temperature T ( prog ) and the deforming strain ε ( deform ). A PLLA–PHBV (6:4 mass ratio) polymer blend was first electrospun into random and aligned fibrous mat forms; thereafter, the effects of applying specific T ( prog ) (37°C and 46°C) and ε ( deform ) (30%, 50%, and 100%) on the morphological change, shape recovery efficiency, and switching temperature T ( sw ) of the two types of fibrous structures were examined under stress-free condition, while the maximum recovery stress σ (max) was determined under constrained recovery condition. It was identified that the applied T ( prog ) had less impact on fiber morphology, but increasing ε ( deform ) gave rise to attenuation in fiber diameters and bettering in fiber orientation, especially for random fibers. The efficiency of shape recovery was found to correlate with both the applied T ( prog ) and ε ( deform ), with the aligned fibers exhibiting relatively higher recovery ability than the random counterpart. Moreover, T ( sw ) was found to be close to T ( prog ), thereby revealing a temperature memory effect in the PLLA–PHBV fibers, with the aligned fibers showing more proximity, while the σ (max) generated was ε ( deform )-dependent and 2.1–3.4 folds stronger for the aligned one in comparison with the random counterpart. Overall, the aligned fibers generally demonstrated better shape memory properties, which can be attributed to the macroscopic structural orderliness and increased molecular orientation and crystallinity imparted during the shape-programming process. Finally, the feasibility of using the shape memory effect to enable a mechanoactive fibrous substrate for regulating osteogenic differentiation of stem cells was demonstrated with the use of aligned fibers. Frontiers Media S.A. 2023-01-26 /pmc/articles/PMC9909598/ /pubmed/36777255 http://dx.doi.org/10.3389/fbioe.2023.1130315 Text en Copyright © 2023 Wang, Zhang, Qin, Guo and Zhang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Bioengineering and Biotechnology Wang, Xianliu Zhang, Zhaowenbin Qin, Chunping Guo, Xuran Zhang, Yanzhong Shape-memory responses compared between random and aligned electrospun fibrous mats |
title | Shape-memory responses compared between random and aligned electrospun fibrous mats |
title_full | Shape-memory responses compared between random and aligned electrospun fibrous mats |
title_fullStr | Shape-memory responses compared between random and aligned electrospun fibrous mats |
title_full_unstemmed | Shape-memory responses compared between random and aligned electrospun fibrous mats |
title_short | Shape-memory responses compared between random and aligned electrospun fibrous mats |
title_sort | shape-memory responses compared between random and aligned electrospun fibrous mats |
topic | Bioengineering and Biotechnology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909598/ https://www.ncbi.nlm.nih.gov/pubmed/36777255 http://dx.doi.org/10.3389/fbioe.2023.1130315 |
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