Cargando…
One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers remains unclear. The aim of this study was to ev...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909601/ https://www.ncbi.nlm.nih.gov/pubmed/36776263 http://dx.doi.org/10.3389/fcvm.2023.1092904 |
_version_ | 1784884608070844416 |
---|---|
author | Cherbi, Miloud Roubille, François Lamblin, Nicolas Bonello, Laurent Leurent, Guillaume Levy, Bruno Elbaz, Meyer Champion, Sebastien Lim, Pascal Schneider, Francis Cariou, Alain Khachab, Hadi Bourenne, Jeremy Seronde, Marie-France Schurtz, Guillaume Harbaoui, Brahim Vanzetto, Gerald Quentin, Charlotte Delabranche, Xavier Aissaoui, Nadia Combaret, Nicolas Tomasevic, Danka Marchandot, Benjamin Lattuca, Benoit Henry, Patrick Gerbaud, Edouard Bonnefoy, Eric Puymirat, Etienne Maury, Philippe Delmas, Clément |
author_facet | Cherbi, Miloud Roubille, François Lamblin, Nicolas Bonello, Laurent Leurent, Guillaume Levy, Bruno Elbaz, Meyer Champion, Sebastien Lim, Pascal Schneider, Francis Cariou, Alain Khachab, Hadi Bourenne, Jeremy Seronde, Marie-France Schurtz, Guillaume Harbaoui, Brahim Vanzetto, Gerald Quentin, Charlotte Delabranche, Xavier Aissaoui, Nadia Combaret, Nicolas Tomasevic, Danka Marchandot, Benjamin Lattuca, Benoit Henry, Patrick Gerbaud, Edouard Bonnefoy, Eric Puymirat, Etienne Maury, Philippe Delmas, Clément |
author_sort | Cherbi, Miloud |
collection | PubMed |
description | BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers remains unclear. The aim of this study was to evaluate 1-year outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS. METHODS: FRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population. RESULTS: Within 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02). CONCLUSION: VA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov, identifier NCT02703038. |
format | Online Article Text |
id | pubmed-9909601 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99096012023-02-10 One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry Cherbi, Miloud Roubille, François Lamblin, Nicolas Bonello, Laurent Leurent, Guillaume Levy, Bruno Elbaz, Meyer Champion, Sebastien Lim, Pascal Schneider, Francis Cariou, Alain Khachab, Hadi Bourenne, Jeremy Seronde, Marie-France Schurtz, Guillaume Harbaoui, Brahim Vanzetto, Gerald Quentin, Charlotte Delabranche, Xavier Aissaoui, Nadia Combaret, Nicolas Tomasevic, Danka Marchandot, Benjamin Lattuca, Benoit Henry, Patrick Gerbaud, Edouard Bonnefoy, Eric Puymirat, Etienne Maury, Philippe Delmas, Clément Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers remains unclear. The aim of this study was to evaluate 1-year outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS. METHODS: FRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population. RESULTS: Within 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02). CONCLUSION: VA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov, identifier NCT02703038. Frontiers Media S.A. 2023-01-26 /pmc/articles/PMC9909601/ /pubmed/36776263 http://dx.doi.org/10.3389/fcvm.2023.1092904 Text en Copyright © 2023 Cherbi, Roubille, Lamblin, Bonello, Leurent, Levy, Elbaz, Champion, Lim, Schneider, Cariou, Khachab, Bourenne, Seronde, Schurtz, Harbaoui, Vanzetto, Quentin, Delabranche, Aissaoui, Combaret, Tomasevic, Marchandot, Lattuca, Henry, Gerbaud, Bonnefoy, Puymirat, Maury and Delmas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cardiovascular Medicine Cherbi, Miloud Roubille, François Lamblin, Nicolas Bonello, Laurent Leurent, Guillaume Levy, Bruno Elbaz, Meyer Champion, Sebastien Lim, Pascal Schneider, Francis Cariou, Alain Khachab, Hadi Bourenne, Jeremy Seronde, Marie-France Schurtz, Guillaume Harbaoui, Brahim Vanzetto, Gerald Quentin, Charlotte Delabranche, Xavier Aissaoui, Nadia Combaret, Nicolas Tomasevic, Danka Marchandot, Benjamin Lattuca, Benoit Henry, Patrick Gerbaud, Edouard Bonnefoy, Eric Puymirat, Etienne Maury, Philippe Delmas, Clément One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry |
title | One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry |
title_full | One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry |
title_fullStr | One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry |
title_full_unstemmed | One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry |
title_short | One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry |
title_sort | one-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: an analysis of the frenshock multicenter prospective registry |
topic | Cardiovascular Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909601/ https://www.ncbi.nlm.nih.gov/pubmed/36776263 http://dx.doi.org/10.3389/fcvm.2023.1092904 |
work_keys_str_mv | AT cherbimiloud oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT roubillefrancois oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT lamblinnicolas oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT bonellolaurent oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT leurentguillaume oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT levybruno oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT elbazmeyer oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT championsebastien oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT limpascal oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT schneiderfrancis oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT carioualain oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT khachabhadi oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT bourennejeremy oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT serondemariefrance oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT schurtzguillaume oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT harbaouibrahim oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT vanzettogerald oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT quentincharlotte oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT delabranchexavier oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT aissaouinadia oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT combaretnicolas oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT tomasevicdanka oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT marchandotbenjamin oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT lattucabenoit oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT henrypatrick oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT gerbaudedouard oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT bonnefoyeric oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT puymiratetienne oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT mauryphilippe oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry AT delmasclement oneyearoutcomesincardiogenicshocktriggeredbyventriculararrhythmiaananalysisofthefrenshockmulticenterprospectiveregistry |