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One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry

BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers  remains  unclear.  The  aim  of  this  study  was  to  ev...

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Autores principales: Cherbi, Miloud, Roubille, François, Lamblin, Nicolas, Bonello, Laurent, Leurent, Guillaume, Levy, Bruno, Elbaz, Meyer, Champion, Sebastien, Lim, Pascal, Schneider, Francis, Cariou, Alain, Khachab, Hadi, Bourenne, Jeremy, Seronde, Marie-France, Schurtz, Guillaume, Harbaoui, Brahim, Vanzetto, Gerald, Quentin, Charlotte, Delabranche, Xavier, Aissaoui, Nadia, Combaret, Nicolas, Tomasevic, Danka, Marchandot, Benjamin, Lattuca, Benoit, Henry, Patrick, Gerbaud, Edouard, Bonnefoy, Eric, Puymirat, Etienne, Maury, Philippe, Delmas, Clément
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909601/
https://www.ncbi.nlm.nih.gov/pubmed/36776263
http://dx.doi.org/10.3389/fcvm.2023.1092904
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author Cherbi, Miloud
Roubille, François
Lamblin, Nicolas
Bonello, Laurent
Leurent, Guillaume
Levy, Bruno
Elbaz, Meyer
Champion, Sebastien
Lim, Pascal
Schneider, Francis
Cariou, Alain
Khachab, Hadi
Bourenne, Jeremy
Seronde, Marie-France
Schurtz, Guillaume
Harbaoui, Brahim
Vanzetto, Gerald
Quentin, Charlotte
Delabranche, Xavier
Aissaoui, Nadia
Combaret, Nicolas
Tomasevic, Danka
Marchandot, Benjamin
Lattuca, Benoit
Henry, Patrick
Gerbaud, Edouard
Bonnefoy, Eric
Puymirat, Etienne
Maury, Philippe
Delmas, Clément
author_facet Cherbi, Miloud
Roubille, François
Lamblin, Nicolas
Bonello, Laurent
Leurent, Guillaume
Levy, Bruno
Elbaz, Meyer
Champion, Sebastien
Lim, Pascal
Schneider, Francis
Cariou, Alain
Khachab, Hadi
Bourenne, Jeremy
Seronde, Marie-France
Schurtz, Guillaume
Harbaoui, Brahim
Vanzetto, Gerald
Quentin, Charlotte
Delabranche, Xavier
Aissaoui, Nadia
Combaret, Nicolas
Tomasevic, Danka
Marchandot, Benjamin
Lattuca, Benoit
Henry, Patrick
Gerbaud, Edouard
Bonnefoy, Eric
Puymirat, Etienne
Maury, Philippe
Delmas, Clément
author_sort Cherbi, Miloud
collection PubMed
description BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers  remains  unclear.  The  aim  of  this  study  was  to  evaluate  1-year  outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS. METHODS: FRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population. RESULTS: Within 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02). CONCLUSION: VA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov, identifier NCT02703038.
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spelling pubmed-99096012023-02-10 One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry Cherbi, Miloud Roubille, François Lamblin, Nicolas Bonello, Laurent Leurent, Guillaume Levy, Bruno Elbaz, Meyer Champion, Sebastien Lim, Pascal Schneider, Francis Cariou, Alain Khachab, Hadi Bourenne, Jeremy Seronde, Marie-France Schurtz, Guillaume Harbaoui, Brahim Vanzetto, Gerald Quentin, Charlotte Delabranche, Xavier Aissaoui, Nadia Combaret, Nicolas Tomasevic, Danka Marchandot, Benjamin Lattuca, Benoit Henry, Patrick Gerbaud, Edouard Bonnefoy, Eric Puymirat, Etienne Maury, Philippe Delmas, Clément Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Cardiogenic shock (CS) is a life-threatening condition carrying poor prognosis, potentially triggered by ventricular arrhythmia (VA). Whether the occurrence of VA as trigger of CS worsens the prognosis compared to non-VA triggers  remains  unclear.  The  aim  of  this  study  was  to  evaluate  1-year  outcomes [mortality, heart transplantation, ventricular assist devices (VAD)] between VA-triggered and non-VA-triggered CS. METHODS: FRENSHOCK is a prospective multicenter registry including 772 CS patients from 49 centers. One to three triggers can be identified in the registry (ischemic, mechanical complications, ventricular/supraventricular arrhythmia, bradycardia, iatrogenesis, infection, non-compliance). Baseline characteristics, management and 1-year outcomes were analyzed according to the VA-trigger in the CS population. RESULTS: Within 769 CS patients included, 94 were VA-triggered (12.2%) and were compared to others. At 1 year, although there was no mortality difference [42.6 vs. 45.3%, HR 0.94 (0.67–1.30), p = 0.7], VA-triggered CS resulted in more heart transplantations and VAD (17 vs. 9%, p = 0.02). Into VA-triggered CS group, though there was no 1-year mortality difference between ischemic and non-ischemic cardiomyopathies [42.5 vs. 42.6%, HR 0.97 (0.52–1.81), p = 0.92], non-ischemic cardiomyopathy led to more heart transplantations and VAD (25.9 vs. 5%, p = 0.02). CONCLUSION: VA-triggered CS did not show higher mortality compared to other triggers but resulted in more heart transplantation and VAD at 1 year, especially in non-ischemic cardiomyopathy, suggesting the need for earlier evaluation by advanced heart failure specialized team for a possible indication of mechanical circulatory support or heart transplantation. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov, identifier NCT02703038. Frontiers Media S.A. 2023-01-26 /pmc/articles/PMC9909601/ /pubmed/36776263 http://dx.doi.org/10.3389/fcvm.2023.1092904 Text en Copyright © 2023 Cherbi, Roubille, Lamblin, Bonello, Leurent, Levy, Elbaz, Champion, Lim, Schneider, Cariou, Khachab, Bourenne, Seronde, Schurtz, Harbaoui, Vanzetto, Quentin, Delabranche, Aissaoui, Combaret, Tomasevic, Marchandot, Lattuca, Henry, Gerbaud, Bonnefoy, Puymirat, Maury and Delmas. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Cherbi, Miloud
Roubille, François
Lamblin, Nicolas
Bonello, Laurent
Leurent, Guillaume
Levy, Bruno
Elbaz, Meyer
Champion, Sebastien
Lim, Pascal
Schneider, Francis
Cariou, Alain
Khachab, Hadi
Bourenne, Jeremy
Seronde, Marie-France
Schurtz, Guillaume
Harbaoui, Brahim
Vanzetto, Gerald
Quentin, Charlotte
Delabranche, Xavier
Aissaoui, Nadia
Combaret, Nicolas
Tomasevic, Danka
Marchandot, Benjamin
Lattuca, Benoit
Henry, Patrick
Gerbaud, Edouard
Bonnefoy, Eric
Puymirat, Etienne
Maury, Philippe
Delmas, Clément
One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
title One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
title_full One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
title_fullStr One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
title_full_unstemmed One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
title_short One-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: An analysis of the FRENSHOCK multicenter prospective registry
title_sort one-year outcomes in cardiogenic shock triggered by ventricular arrhythmia: an analysis of the frenshock multicenter prospective registry
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909601/
https://www.ncbi.nlm.nih.gov/pubmed/36776263
http://dx.doi.org/10.3389/fcvm.2023.1092904
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