Inhibiting the transcription and replication of Ebola viruses by disrupting the nucleoprotein and VP30 protein interaction with small molecules

Ebola virus (EBOV) causes hemorrhagic fever in humans with high morbidity and fatality. Although over 45 years have passed since the first EBOV outbreak, small molecule drugs are not yet available. Ebola viral protein VP30 is a unique RNA synthesis cofactor, and the VP30/NP interaction plays a criti...

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Detalles Bibliográficos
Autores principales: Ma, Yan-hong, Hong, Xu, Wu, Fang, Xu, Xin-feng, Li, Rui, Zhong, Jin, Zhou, Yao-qi, Liu, Shu-wen, Zhan, Jian, Xu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909651/
https://www.ncbi.nlm.nih.gov/pubmed/36759643
http://dx.doi.org/10.1038/s41401-023-01055-0

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