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Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis
[Image: see text] As novel wound dressings, cryogels with rapid hemostatic property and good sterilization effect are urgently desirable for wound healing. To reduce the use of antibiotics, antibacterial photothermal therapy with broad-spectrum bactericidal capacity and non-obvious bacterial resista...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909789/ https://www.ncbi.nlm.nih.gov/pubmed/36777611 http://dx.doi.org/10.1021/acsomega.2c07170 |
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author | Lin, Xiao Duan, Yuxi Lan, Qian Xu, Yueying Xia, Yu Huang, Zhuoyi Song, Lijun Zhang, Yang Guo, Ning |
author_facet | Lin, Xiao Duan, Yuxi Lan, Qian Xu, Yueying Xia, Yu Huang, Zhuoyi Song, Lijun Zhang, Yang Guo, Ning |
author_sort | Lin, Xiao |
collection | PubMed |
description | [Image: see text] As novel wound dressings, cryogels with rapid hemostatic property and good sterilization effect are urgently desirable for wound healing. To reduce the use of antibiotics, antibacterial photothermal therapy with broad-spectrum bactericidal capacity and non-obvious bacterial resistance has been widely researched. However, photothermal agents usually suffer from poor hemostatic ability. In this research, sodium alginate (SA) and epigallocatechin gallate (EGCG) were non-covalently cross-linked in suit by ferric ions to obtain SA/EGCG/Fe (SEF) cryogels after lyophilization as an antibacterial wound dressing. Next, its photothermal performance was intensively assessed. Moreover, its hemostasis and bactericidal effect were evaluated. First, it displayed extraordinary photothermal ability owing to the formation of Fe(3+)/EGCG-based metal phenolic networks (MPNs) inside the SEF cryogel. Furthermore, in vitro and in vivo assays illustrated that it exhibits rapid hemostatic capacity owing to its high porosity and MPN-mediated cell adhesion capacity. In conclusion, the SEF cryogel manifests satisfactory hemostatic and bactericidal properties. Therefore, it is a promising wound-dressing candidate for clinical applications. |
format | Online Article Text |
id | pubmed-9909789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99097892023-02-10 Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis Lin, Xiao Duan, Yuxi Lan, Qian Xu, Yueying Xia, Yu Huang, Zhuoyi Song, Lijun Zhang, Yang Guo, Ning ACS Omega [Image: see text] As novel wound dressings, cryogels with rapid hemostatic property and good sterilization effect are urgently desirable for wound healing. To reduce the use of antibiotics, antibacterial photothermal therapy with broad-spectrum bactericidal capacity and non-obvious bacterial resistance has been widely researched. However, photothermal agents usually suffer from poor hemostatic ability. In this research, sodium alginate (SA) and epigallocatechin gallate (EGCG) were non-covalently cross-linked in suit by ferric ions to obtain SA/EGCG/Fe (SEF) cryogels after lyophilization as an antibacterial wound dressing. Next, its photothermal performance was intensively assessed. Moreover, its hemostasis and bactericidal effect were evaluated. First, it displayed extraordinary photothermal ability owing to the formation of Fe(3+)/EGCG-based metal phenolic networks (MPNs) inside the SEF cryogel. Furthermore, in vitro and in vivo assays illustrated that it exhibits rapid hemostatic capacity owing to its high porosity and MPN-mediated cell adhesion capacity. In conclusion, the SEF cryogel manifests satisfactory hemostatic and bactericidal properties. Therefore, it is a promising wound-dressing candidate for clinical applications. American Chemical Society 2023-01-27 /pmc/articles/PMC9909789/ /pubmed/36777611 http://dx.doi.org/10.1021/acsomega.2c07170 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Lin, Xiao Duan, Yuxi Lan, Qian Xu, Yueying Xia, Yu Huang, Zhuoyi Song, Lijun Zhang, Yang Guo, Ning Alginate-Based Cryogels for Combined Chemo/Photothermal Antibacterial Therapy and Rapid Hemostasis |
title | Alginate-Based
Cryogels for Combined Chemo/Photothermal
Antibacterial Therapy and Rapid Hemostasis |
title_full | Alginate-Based
Cryogels for Combined Chemo/Photothermal
Antibacterial Therapy and Rapid Hemostasis |
title_fullStr | Alginate-Based
Cryogels for Combined Chemo/Photothermal
Antibacterial Therapy and Rapid Hemostasis |
title_full_unstemmed | Alginate-Based
Cryogels for Combined Chemo/Photothermal
Antibacterial Therapy and Rapid Hemostasis |
title_short | Alginate-Based
Cryogels for Combined Chemo/Photothermal
Antibacterial Therapy and Rapid Hemostasis |
title_sort | alginate-based
cryogels for combined chemo/photothermal
antibacterial therapy and rapid hemostasis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909789/ https://www.ncbi.nlm.nih.gov/pubmed/36777611 http://dx.doi.org/10.1021/acsomega.2c07170 |
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