Cargando…

Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event

INTRODUCTION: Contralateral axillary lymph node metastasis (CALNM) in breast cancer (BC) is considered a distant metastasis, marking stage 4cancer. Therefore, it is generally treated as an incurable disease. However, in clinical practice, staging and treatment remain controversial due to a paucity o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zwimpfer, Tibor A., Schwab, Fabienne D., Steffens, Daniel, Kaul, Felix, Schmidt, Noemi, Geiger, James, Geissler, Franziska, Heinzelmann-Schwarz, Viola, Weber, Walter P., Kurzeder, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909893/
https://www.ncbi.nlm.nih.gov/pubmed/36755294
http://dx.doi.org/10.1186/s12957-023-02918-w
_version_ 1784884671316754432
author Zwimpfer, Tibor A.
Schwab, Fabienne D.
Steffens, Daniel
Kaul, Felix
Schmidt, Noemi
Geiger, James
Geissler, Franziska
Heinzelmann-Schwarz, Viola
Weber, Walter P.
Kurzeder, Christian
author_facet Zwimpfer, Tibor A.
Schwab, Fabienne D.
Steffens, Daniel
Kaul, Felix
Schmidt, Noemi
Geiger, James
Geissler, Franziska
Heinzelmann-Schwarz, Viola
Weber, Walter P.
Kurzeder, Christian
author_sort Zwimpfer, Tibor A.
collection PubMed
description INTRODUCTION: Contralateral axillary lymph node metastasis (CALNM) in breast cancer (BC) is considered a distant metastasis, marking stage 4cancer. Therefore, it is generally treated as an incurable disease. However, in clinical practice, staging and treatment remain controversial due to a paucity of data, and the St. Gallen 2021 consensus panel recommended a curative approach in patients with oligometastatic disease. Aberrant lymph node (LN) drainage following previous surgery or radiotherapy is common. Therefore, CALNM may be considered a regional event rather than systemic disease, and a re-sentinel procedure aided by lymphoscintigraphy permits adequate regional staging. CASE REPORT: Here, we report a 37-year-old patient with Lynch syndrome who presented with CALNM in an ipsilateral relapse of a moderately differentiated invasive ductal BC (ER 90%, PR 30%, HER2 negative, Ki-67 25%, microsatellite stable), 3 years after the initial diagnosis. Lymphoscintigraphy detected a positive sentinel LN in the contralateral axilla despite no sign of LN involvement or distant metastases on FDG PET/CT or MRI. The patient underwent bilateral mastectomy with sentinel node dissection, surgical reconstruction with histological confirmation of the CALNM, left axillary dissection, adjuvant chemotherapy, and anti-hormone therapy. In addition to her regular BC follow-up visits, the patient will undergo annual colonoscopy, gastroscopy, abdominal, and vaginal ultrasound screening. In January 2023, the patient was free of progression for 23 months after initiation of treatment for recurrent BC and CALNM. CONCLUSION: This case highlights the value of delayed lymphoscintigraphy and the contribution of sentinel procedure for local control in the setting of recurrent BC. Aberrant lymph node drainage following previous surgery may be the underlying cause of CALNM. We propose that CALNM without evidence of systemic metastasis should be considered a regional event in recurrent BC, and thus, a curative approach can be pursued. The next AJCC BC staging should clarify the role of CALNM in recurrent BC to allow for the development of specific treatment guidelines.
format Online
Article
Text
id pubmed-9909893
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-99098932023-02-10 Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event Zwimpfer, Tibor A. Schwab, Fabienne D. Steffens, Daniel Kaul, Felix Schmidt, Noemi Geiger, James Geissler, Franziska Heinzelmann-Schwarz, Viola Weber, Walter P. Kurzeder, Christian World J Surg Oncol Case Report INTRODUCTION: Contralateral axillary lymph node metastasis (CALNM) in breast cancer (BC) is considered a distant metastasis, marking stage 4cancer. Therefore, it is generally treated as an incurable disease. However, in clinical practice, staging and treatment remain controversial due to a paucity of data, and the St. Gallen 2021 consensus panel recommended a curative approach in patients with oligometastatic disease. Aberrant lymph node (LN) drainage following previous surgery or radiotherapy is common. Therefore, CALNM may be considered a regional event rather than systemic disease, and a re-sentinel procedure aided by lymphoscintigraphy permits adequate regional staging. CASE REPORT: Here, we report a 37-year-old patient with Lynch syndrome who presented with CALNM in an ipsilateral relapse of a moderately differentiated invasive ductal BC (ER 90%, PR 30%, HER2 negative, Ki-67 25%, microsatellite stable), 3 years after the initial diagnosis. Lymphoscintigraphy detected a positive sentinel LN in the contralateral axilla despite no sign of LN involvement or distant metastases on FDG PET/CT or MRI. The patient underwent bilateral mastectomy with sentinel node dissection, surgical reconstruction with histological confirmation of the CALNM, left axillary dissection, adjuvant chemotherapy, and anti-hormone therapy. In addition to her regular BC follow-up visits, the patient will undergo annual colonoscopy, gastroscopy, abdominal, and vaginal ultrasound screening. In January 2023, the patient was free of progression for 23 months after initiation of treatment for recurrent BC and CALNM. CONCLUSION: This case highlights the value of delayed lymphoscintigraphy and the contribution of sentinel procedure for local control in the setting of recurrent BC. Aberrant lymph node drainage following previous surgery may be the underlying cause of CALNM. We propose that CALNM without evidence of systemic metastasis should be considered a regional event in recurrent BC, and thus, a curative approach can be pursued. The next AJCC BC staging should clarify the role of CALNM in recurrent BC to allow for the development of specific treatment guidelines. BioMed Central 2023-02-09 /pmc/articles/PMC9909893/ /pubmed/36755294 http://dx.doi.org/10.1186/s12957-023-02918-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Zwimpfer, Tibor A.
Schwab, Fabienne D.
Steffens, Daniel
Kaul, Felix
Schmidt, Noemi
Geiger, James
Geissler, Franziska
Heinzelmann-Schwarz, Viola
Weber, Walter P.
Kurzeder, Christian
Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
title Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
title_full Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
title_fullStr Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
title_full_unstemmed Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
title_short Contralateral lymph node metastasis in recurrent ipsilateral breast cancer with Lynch syndrome: a locoregional event
title_sort contralateral lymph node metastasis in recurrent ipsilateral breast cancer with lynch syndrome: a locoregional event
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909893/
https://www.ncbi.nlm.nih.gov/pubmed/36755294
http://dx.doi.org/10.1186/s12957-023-02918-w
work_keys_str_mv AT zwimpfertibora contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT schwabfabienned contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT steffensdaniel contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT kaulfelix contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT schmidtnoemi contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT geigerjames contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT geisslerfranziska contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT heinzelmannschwarzviola contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT weberwalterp contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent
AT kurzederchristian contralaterallymphnodemetastasisinrecurrentipsilateralbreastcancerwithlynchsyndromealocoregionalevent