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Genetic models of cleavage-reduced and soluble TREM2 reveal distinct effects on myelination and microglia function in the cuprizone model

Triggering receptor expressed on myeloid cells 2 (TREM2) is a cell-surface immunoreceptor expressed on microglia, osteoclasts, dendritic cells and macrophages. Heterozygous loss-of-function mutations in TREM2, including mutations enhancing shedding form the cell surface, have been associated with my...

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Detalles Bibliográficos
Autores principales:	Beckmann, Nicolau, Neuhaus, Anna, Zurbruegg, Stefan, Volkmer, Pia, Patino, Claudia, Joller, Stefanie, Feuerbach, Dominik, Doelemeyer, Arno, Schweizer, Tatjana, Rudin, Stefan, Neumann, Ulf, Berth, Ramon, Frieauff, Wilfried, Gasparini, Fabrizio, Shimshek, Derya R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909920/ https://www.ncbi.nlm.nih.gov/pubmed/36755323 http://dx.doi.org/10.1186/s12974-022-02671-z

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