Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex

Treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has brought significant benefits to non-small cell lung cancer (NSCLC) patients with EGFR mutations. However, most patients eventually develop acquired resistance after treatment. This study investigated the epi...

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Detalles Bibliográficos
Autores principales: Lin, Shuye, Ruan, Hongyun, Qin, Lin, Zhao, Cong, Gu, Meng, Wang, Ziyu, Liu, Bin, Wang, Haichao, Wang, Jinghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910003/
https://www.ncbi.nlm.nih.gov/pubmed/36778111
http://dx.doi.org/10.7150/ijbs.75963

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910003/
https://www.ncbi.nlm.nih.gov/pubmed/36778111
http://dx.doi.org/10.7150/ijbs.75963

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