Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System

SARS-COV-2 can contribute to long term consequences associated with sepsis and circulatory dysfunction. In this insightful paper, we highlight the emerging pathophysiology utilizing two case examples. Both systemic and organ specific features are discussed. In addition, a novel laboratory assay is p...

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Autores principales: Sizemore, Gina, Lucke-Wold, Brandon, Small, Coulter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910055/
https://www.ncbi.nlm.nih.gov/pubmed/36780255
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author Sizemore, Gina
Lucke-Wold, Brandon
Small, Coulter
author_facet Sizemore, Gina
Lucke-Wold, Brandon
Small, Coulter
author_sort Sizemore, Gina
collection PubMed
description SARS-COV-2 can contribute to long term consequences associated with sepsis and circulatory dysfunction. In this insightful paper, we highlight the emerging pathophysiology utilizing two case examples. Both systemic and organ specific features are discussed. In addition, a novel laboratory assay is presented that identified SARS-COV-2 in the circulation using conserved SARS ion channels rather than the spike protein. The presentation is linked to the pathophysiology with the emphasis for early recognition and continued research. This paper will serve as a catalyst for continued discovery.
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spelling pubmed-99100552023-02-09 Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System Sizemore, Gina Lucke-Wold, Brandon Small, Coulter SM J Neurol Disord Stroke Article SARS-COV-2 can contribute to long term consequences associated with sepsis and circulatory dysfunction. In this insightful paper, we highlight the emerging pathophysiology utilizing two case examples. Both systemic and organ specific features are discussed. In addition, a novel laboratory assay is presented that identified SARS-COV-2 in the circulation using conserved SARS ion channels rather than the spike protein. The presentation is linked to the pathophysiology with the emphasis for early recognition and continued research. This paper will serve as a catalyst for continued discovery. 2022 2022-12-01 /pmc/articles/PMC9910055/ /pubmed/36780255 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Sizemore, Gina
Lucke-Wold, Brandon
Small, Coulter
Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System
title Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System
title_full Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System
title_fullStr Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System
title_full_unstemmed Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System
title_short Review of SARS-COV-2 Systemic Impact: Building the Case for Sepsis via Virus in the Circulatory System
title_sort review of sars-cov-2 systemic impact: building the case for sepsis via virus in the circulatory system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910055/
https://www.ncbi.nlm.nih.gov/pubmed/36780255
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