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COMMD proteins function and their regulating roles in tumors
The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associat...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910083/ https://www.ncbi.nlm.nih.gov/pubmed/36776284 http://dx.doi.org/10.3389/fonc.2023.1067234 |
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author | You, Guangqiang Zhou, Chen Wang, Lei Liu, Zefeng Fang, He Yao, Xiaoxao Zhang, Xuewen |
author_facet | You, Guangqiang Zhou, Chen Wang, Lei Liu, Zefeng Fang, He Yao, Xiaoxao Zhang, Xuewen |
author_sort | You, Guangqiang |
collection | PubMed |
description | The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial. |
format | Online Article Text |
id | pubmed-9910083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99100832023-02-10 COMMD proteins function and their regulating roles in tumors You, Guangqiang Zhou, Chen Wang, Lei Liu, Zefeng Fang, He Yao, Xiaoxao Zhang, Xuewen Front Oncol Oncology The COMMD proteins are a highly conserved protein family with ten members that play a crucial role in a variety of biological activities, including copper metabolism, endosomal sorting, ion transport, and other processes. Recent research have demonstrated that the COMMD proteins are closely associated with a wide range of disorders, such as hepatitis, myocardial ischemia, cerebral ischemia, HIV infection, and cancer. Among these, the role of COMMD proteins in tumors has been thoroughly explored; they promote or inhibit cancers such as lung cancer, liver cancer, gastric cancer, and prostate cancer. COMMD proteins can influence tumor proliferation, invasion, metastasis, and tumor angiogenesis, which are strongly related to the prognosis of tumors and are possible therapeutic targets for treating tumors. In terms of molecular mechanism, COMMD proteins in tumor cells regulate the oncogenes of NF-κB, HIF, c-MYC, and others, and are related to signaling pathways including apoptosis, autophagy, and ferroptosis. For the clinical diagnosis and therapy of malignancies, additional research into the involvement of COMMD proteins in cancer is beneficial. Frontiers Media S.A. 2023-01-23 /pmc/articles/PMC9910083/ /pubmed/36776284 http://dx.doi.org/10.3389/fonc.2023.1067234 Text en Copyright © 2023 You, Zhou, Wang, Liu, Fang, Yao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology You, Guangqiang Zhou, Chen Wang, Lei Liu, Zefeng Fang, He Yao, Xiaoxao Zhang, Xuewen COMMD proteins function and their regulating roles in tumors |
title | COMMD proteins function and their regulating roles in tumors |
title_full | COMMD proteins function and their regulating roles in tumors |
title_fullStr | COMMD proteins function and their regulating roles in tumors |
title_full_unstemmed | COMMD proteins function and their regulating roles in tumors |
title_short | COMMD proteins function and their regulating roles in tumors |
title_sort | commd proteins function and their regulating roles in tumors |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910083/ https://www.ncbi.nlm.nih.gov/pubmed/36776284 http://dx.doi.org/10.3389/fonc.2023.1067234 |
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