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The role of pyroptosis in endothelial dysfunction induced by diseases
Most organs in the body rely on blood flow, and vesicular damage is the leading cause of injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in ensuring vascular homeostasis and angiogenesis. The rapid development of risk factors in endothelial injuries has b...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910335/ https://www.ncbi.nlm.nih.gov/pubmed/36776394 http://dx.doi.org/10.3389/fimmu.2022.1093985 |
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author | Ju, Jin Liu, Yanyan Liang, Haihai Yang, Baofeng |
author_facet | Ju, Jin Liu, Yanyan Liang, Haihai Yang, Baofeng |
author_sort | Ju, Jin |
collection | PubMed |
description | Most organs in the body rely on blood flow, and vesicular damage is the leading cause of injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in ensuring vascular homeostasis and angiogenesis. The rapid development of risk factors in endothelial injuries has been seen in the past decade, such as smoking, infectious, and diabetes mellites. Pyroptotic endothelium is an inflammatory mode of governed endothelial cell death that depend on the metabolic disorder and severe infectious such as atherosclerosis, and sepsis-related acute lung injury, respectively. Pyroptotic endothelial cells need GSDMD cleaved into N- and C-terminal by caspase1, and the cytokines are released by a pore constructed by the N-terminal of GSDMD in the membrane of ECs, finally resulting in severe inflammation and pyroptotic cell death. This review will focus on the patho-physiological and pharmacological pathways of pyroptotic endothelial metabolism in diseases. Overall, this review indicates that pyroptosis is a significant risk factor in diseases and a potential drug target in related diseases. |
format | Online Article Text |
id | pubmed-9910335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99103352023-02-10 The role of pyroptosis in endothelial dysfunction induced by diseases Ju, Jin Liu, Yanyan Liang, Haihai Yang, Baofeng Front Immunol Immunology Most organs in the body rely on blood flow, and vesicular damage is the leading cause of injury in multiple organs. The endothelium, as the barriers of vessels, play a critical role in ensuring vascular homeostasis and angiogenesis. The rapid development of risk factors in endothelial injuries has been seen in the past decade, such as smoking, infectious, and diabetes mellites. Pyroptotic endothelium is an inflammatory mode of governed endothelial cell death that depend on the metabolic disorder and severe infectious such as atherosclerosis, and sepsis-related acute lung injury, respectively. Pyroptotic endothelial cells need GSDMD cleaved into N- and C-terminal by caspase1, and the cytokines are released by a pore constructed by the N-terminal of GSDMD in the membrane of ECs, finally resulting in severe inflammation and pyroptotic cell death. This review will focus on the patho-physiological and pharmacological pathways of pyroptotic endothelial metabolism in diseases. Overall, this review indicates that pyroptosis is a significant risk factor in diseases and a potential drug target in related diseases. Frontiers Media S.A. 2023-01-09 /pmc/articles/PMC9910335/ /pubmed/36776394 http://dx.doi.org/10.3389/fimmu.2022.1093985 Text en Copyright © 2023 Ju, Liu, Liang and Yang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Ju, Jin Liu, Yanyan Liang, Haihai Yang, Baofeng The role of pyroptosis in endothelial dysfunction induced by diseases |
title | The role of pyroptosis in endothelial dysfunction induced by diseases |
title_full | The role of pyroptosis in endothelial dysfunction induced by diseases |
title_fullStr | The role of pyroptosis in endothelial dysfunction induced by diseases |
title_full_unstemmed | The role of pyroptosis in endothelial dysfunction induced by diseases |
title_short | The role of pyroptosis in endothelial dysfunction induced by diseases |
title_sort | role of pyroptosis in endothelial dysfunction induced by diseases |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910335/ https://www.ncbi.nlm.nih.gov/pubmed/36776394 http://dx.doi.org/10.3389/fimmu.2022.1093985 |
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