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Recent progress in synthesis and application of furoxan
This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction condit...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910416/ https://www.ncbi.nlm.nih.gov/pubmed/36777951 http://dx.doi.org/10.1039/d3ra00189j |
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author | Abu Yousef, Muhammad Matsubara, Ryosuke |
author_facet | Abu Yousef, Muhammad Matsubara, Ryosuke |
author_sort | Abu Yousef, Muhammad |
collection | PubMed |
description | This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction conditions. Nevertheless, recent studies have conducted a variety of bond-forming reactions on the furoxan ring via a post-ring introduction of substituents (PRIS) strategy. This strategy enables the synthesis of furoxan molecules of interest more directly than the conventional methods that rely on the pre-installation of substituents on the furoxan ring precursors. In this review, the PRIS strategy for furoxan synthesis is classified and discussed according to the type of bond formed. Additionally, recent progress in the application of furoxan molecules, predominantly facilitated by the development of new synthetic methods, is covered in this review. |
format | Online Article Text |
id | pubmed-9910416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-99104162023-02-10 Recent progress in synthesis and application of furoxan Abu Yousef, Muhammad Matsubara, Ryosuke RSC Adv Chemistry This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction conditions. Nevertheless, recent studies have conducted a variety of bond-forming reactions on the furoxan ring via a post-ring introduction of substituents (PRIS) strategy. This strategy enables the synthesis of furoxan molecules of interest more directly than the conventional methods that rely on the pre-installation of substituents on the furoxan ring precursors. In this review, the PRIS strategy for furoxan synthesis is classified and discussed according to the type of bond formed. Additionally, recent progress in the application of furoxan molecules, predominantly facilitated by the development of new synthetic methods, is covered in this review. The Royal Society of Chemistry 2023-02-09 /pmc/articles/PMC9910416/ /pubmed/36777951 http://dx.doi.org/10.1039/d3ra00189j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Abu Yousef, Muhammad Matsubara, Ryosuke Recent progress in synthesis and application of furoxan |
title | Recent progress in synthesis and application of furoxan |
title_full | Recent progress in synthesis and application of furoxan |
title_fullStr | Recent progress in synthesis and application of furoxan |
title_full_unstemmed | Recent progress in synthesis and application of furoxan |
title_short | Recent progress in synthesis and application of furoxan |
title_sort | recent progress in synthesis and application of furoxan |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910416/ https://www.ncbi.nlm.nih.gov/pubmed/36777951 http://dx.doi.org/10.1039/d3ra00189j |
work_keys_str_mv | AT abuyousefmuhammad recentprogressinsynthesisandapplicationoffuroxan AT matsubararyosuke recentprogressinsynthesisandapplicationoffuroxan |