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Recent progress in synthesis and application of furoxan

This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction condit...

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Detalles Bibliográficos
Autores principales: Abu Yousef, Muhammad, Matsubara, Ryosuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910416/
https://www.ncbi.nlm.nih.gov/pubmed/36777951
http://dx.doi.org/10.1039/d3ra00189j
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author Abu Yousef, Muhammad
Matsubara, Ryosuke
author_facet Abu Yousef, Muhammad
Matsubara, Ryosuke
author_sort Abu Yousef, Muhammad
collection PubMed
description This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction conditions. Nevertheless, recent studies have conducted a variety of bond-forming reactions on the furoxan ring via a post-ring introduction of substituents (PRIS) strategy. This strategy enables the synthesis of furoxan molecules of interest more directly than the conventional methods that rely on the pre-installation of substituents on the furoxan ring precursors. In this review, the PRIS strategy for furoxan synthesis is classified and discussed according to the type of bond formed. Additionally, recent progress in the application of furoxan molecules, predominantly facilitated by the development of new synthetic methods, is covered in this review.
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spelling pubmed-99104162023-02-10 Recent progress in synthesis and application of furoxan Abu Yousef, Muhammad Matsubara, Ryosuke RSC Adv Chemistry This review highlights recent developments in the synthesis and application of furoxan. The chemistry of furoxan is relatively underdeveloped compared to that of other heterocycles owing to its difficult synthesis, which is ascribed to the labile nature of this molecule under various reaction conditions. Nevertheless, recent studies have conducted a variety of bond-forming reactions on the furoxan ring via a post-ring introduction of substituents (PRIS) strategy. This strategy enables the synthesis of furoxan molecules of interest more directly than the conventional methods that rely on the pre-installation of substituents on the furoxan ring precursors. In this review, the PRIS strategy for furoxan synthesis is classified and discussed according to the type of bond formed. Additionally, recent progress in the application of furoxan molecules, predominantly facilitated by the development of new synthetic methods, is covered in this review. The Royal Society of Chemistry 2023-02-09 /pmc/articles/PMC9910416/ /pubmed/36777951 http://dx.doi.org/10.1039/d3ra00189j Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Abu Yousef, Muhammad
Matsubara, Ryosuke
Recent progress in synthesis and application of furoxan
title Recent progress in synthesis and application of furoxan
title_full Recent progress in synthesis and application of furoxan
title_fullStr Recent progress in synthesis and application of furoxan
title_full_unstemmed Recent progress in synthesis and application of furoxan
title_short Recent progress in synthesis and application of furoxan
title_sort recent progress in synthesis and application of furoxan
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910416/
https://www.ncbi.nlm.nih.gov/pubmed/36777951
http://dx.doi.org/10.1039/d3ra00189j
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