Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

WD repeat domain 5 (WDR5) is a core scaffolding component of many multiprotein complexes that perform a variety of critical chromatin-centric processes in the nucleus. WDR5 is a component of the mixed lineage leukemia MLL/SET complex and localizes MYC to chromatin at tumor-critical target genes. As...

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Detalles Bibliográficos
Autores principales: Teuscher, Kevin B., Chowdhury, Somenath, Meyers, Kenneth M., Tian, Jianhua, Sai, Jiqing, Van Meveren, Mayme, South, Taylor M., Sensintaffar, John L., Rietz, Tyson A., Goswami, Soumita, Wang, Jing, Grieb, Brian C., Lorey, Shelly L., Howard, Gregory C., Liu, Qi, Moore, William J., Stott, Gordon M., Tansey, William P., Lee, Taekyu, Fesik, Stephen W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910433/
https://www.ncbi.nlm.nih.gov/pubmed/36574664
http://dx.doi.org/10.1073/pnas.2211297120

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