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Road-blocker HSP disease mutation disrupts pre-organization for ATP hydrolysis in kinesin through a second sphere control

Kinesin motor proteins perform several essential cellular functions powered by the adenosine triphosphate (ATP) hydrolysis reaction. Several single-point mutations in the kinesin motor protein KIF5A have been implicated to hereditary spastic paraplegia disease (HSP), a lethal neurodegenerative disea...

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Detalles Bibliográficos
Autores principales:	Manna, Rabindra Nath, Onuchic, José N., Jana, Biman
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910451/ https://www.ncbi.nlm.nih.gov/pubmed/36574689 http://dx.doi.org/10.1073/pnas.2215170120

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