Humanized V(D)J-rearranging and TdT-expressing mouse vaccine models with physiological HIV-1 broadly neutralizing antibody precursors

Antibody heavy chain (HC) and light chain (LC) variable region exons are assembled by V(D)J recombination. V(D)J junctional regions encode complementarity-determining-region 3 (CDR3), an antigen-contact region immensely diversified through nontemplated nucleotide additions (“N-regions”) by terminal...

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Detalles Bibliográficos
Autores principales: Luo, Sai, Jing, Changbin, Ye, Adam Yongxin, Kratochvil, Sven, Cottrell, Christopher A., Koo, Ja-Hyun, Chapdelaine Williams, Aimee, Francisco, Lucas Vieira, Batra, Himanshu, Lamperti, Edward, Kalyuzhniy, Oleksandr, Zhang, Yuxiang, Barbieri, Alessandro, Manis, John P., Haynes, Barton F., Schief, William R., Batista, Facundo D., Tian, Ming, Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910454/
https://www.ncbi.nlm.nih.gov/pubmed/36574685
http://dx.doi.org/10.1073/pnas.2217883120

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