The lncRNA LUCAT1 is elevated in inflammatory disease and restrains inflammation by regulating the splicing and stability of NR4A2

The nuclear long non-coding RNA LUCAT1 has previously been identified as a negative feedback regulator of type I interferon and inflammatory cytokine expression in human myeloid cells. Here, we define the mechanistic basis for the suppression of inflammatory gene expression by LUCAT1. Using comprehe...

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Detalles Bibliográficos
Autores principales: Vierbuchen, Tim, Agarwal, Shiuli, Johnson, John L., Galia, Liraz, Lei, Xuqiu, Stein, Karina, Olagnier, David, Gaede, Karoline I., Herzmann, Christian, Holm, Christian K., Heine, Holger, Pai, Athma, O’Hara Hall, Aisling, Hoebe, Kasper, Fitzgerald, Katherine A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910463/
https://www.ncbi.nlm.nih.gov/pubmed/36577072
http://dx.doi.org/10.1073/pnas.2213715120

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