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Computational design of CRISPR guide RNAs to enable strain-specific control of microbial consortia
Microbes naturally coexist in complex, multistrain communities. However, extracting individual microbes from and specifically manipulating the composition of these consortia remain challenging. The sequence-specific nature of CRISPR guide RNAs can be leveraged to accurately differentiate microorgani...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910470/ https://www.ncbi.nlm.nih.gov/pubmed/36574681 http://dx.doi.org/10.1073/pnas.2213154120 |