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Disruption of nucleosomes by DNA groove binders of clinical significance and implications for chromatin remodeling
Small molecules that bind in the minor groove of DNA are in clinical use as antibiotics and antitumor drugs. Two members of this class of molecules, netropsin and chromomycin, are shown here to displace DNA from the nucleosome and promote transfer of the histone octamer to an acceptor protein. The e...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910476/ https://www.ncbi.nlm.nih.gov/pubmed/36574674 http://dx.doi.org/10.1073/pnas.2216611120 |