A RGS7-CaMKII complex drives myocyte-intrinsic and myocyte-extrinsic mechanisms of chemotherapy-induced cardiotoxicity

Dose-limiting cardiotoxicity remains a major limitation in the clinical use of cancer chemotherapeutics. Here, we describe a role for Regulator of G protein Signaling 7 (RGS7) in chemotherapy-dependent heart damage, the demonstration for a functional role of RGS7 outside of the nervous system and re...

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Detalles Bibliográficos
Autores principales: Basak, Madhuri, Sengar, Abhishek Singh, Das, Kiran, Mahata, Tarun, Kumar, Manish, Kumar, Dinesh, Biswas, Sayan, Sarkar, Subhasish, Kumar, Pranesh, Das, Priyadip, Stewart, Adele, Maity, Biswanath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910480/
https://www.ncbi.nlm.nih.gov/pubmed/36574707
http://dx.doi.org/10.1073/pnas.2213537120

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