Crystal structure of LGR ligand α2/β5 from Caenorhabditis elegans with implications for the evolution of glycoprotein hormones

A family of leucine-rich-repeat-containing G-protein-coupled receptors (LGRs) mediate diverse physiological responses when complexed with their cognate ligands. LGRs are present in all metazoan animals. In humans, the LGR ligands include glycoprotein hormones (GPHs) chorionic gonadotropin (hCG), lut...

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Detalles Bibliográficos
Autores principales: Gong, Zhen, Wang, Wei, El Omari, Kamel, Lebedev, Andrey A., Clarke, Oliver B., Hendrickson, Wayne A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910494/
https://www.ncbi.nlm.nih.gov/pubmed/36574673
http://dx.doi.org/10.1073/pnas.2218630120

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