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The chaperone protein p32 stabilizes HIV-1 Tat and strengthens the p-TEFb/RNAPII/TAR complex promoting HIV transcription elongation

HIV gene expression is modulated by the combinatorial activity of the HIV transcriptional activator, Tat, host transcription factors, and chromatin remodeling complexes. To identify host factors regulating HIV transcription, we used specific single-guide RNAs and endonuclease-deficient Cas9 to perfo...

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Detalles Bibliográficos
Autores principales:	Li, Chuan, Mori, Luisa P., Lyu, Shuang, Bronson, Ronald, Getzler, Adam J., Pipkin, Matthew E., Valente, Susana T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910500/ https://www.ncbi.nlm.nih.gov/pubmed/36584296 http://dx.doi.org/10.1073/pnas.2217476120

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