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High-frequency and functional mitochondrial DNA mutations at the single-cell level

Decline in mitochondrial function underlies aging and age-related diseases, but the role of mitochondrial DNA (mtDNA) mutations in these processes remains elusive. To investigate patterns of mtDNA mutations, it is particularly important to quantify mtDNA mutations and their associated pathogenic eff...

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Detalles Bibliográficos
Autores principales:	Guo, Xiaoxian, Xu, Weilin, Zhang, Weiping, Pan, Cuiping, Thalacker-Mercer, Anna E., Zheng, Hongxiang, Gu, Zhenglong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2022
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910596/ https://www.ncbi.nlm.nih.gov/pubmed/36577067 http://dx.doi.org/10.1073/pnas.2201518120

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