Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid

Microglia play a critical role in the clearance of myelin debris, thereby ensuring functional recovery from neural injury. Here, using mouse model of demyelination following two-point LPC injection, we show that the microglial autophagic–lysosomal pathway becomes overactivated in response to severe...

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Detalles Bibliográficos
Autores principales: Zhou, Luo-Qi, Dong, Ming-Hao, Hu, Zi-Wei, Tang, Yue, Chu, Yun-Hui, Chen, Man, Yang, Sheng, Chen, Zhi, Wu, Long-Jun, Wang, Wei, Qin, Chuan, Tian, Dai-Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910603/
https://www.ncbi.nlm.nih.gov/pubmed/36577069
http://dx.doi.org/10.1073/pnas.2209990120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910603/
https://www.ncbi.nlm.nih.gov/pubmed/36577069
http://dx.doi.org/10.1073/pnas.2209990120

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