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Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid
Microglia play a critical role in the clearance of myelin debris, thereby ensuring functional recovery from neural injury. Here, using mouse model of demyelination following two-point LPC injection, we show that the microglial autophagic–lysosomal pathway becomes overactivated in response to severe...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910603/ https://www.ncbi.nlm.nih.gov/pubmed/36577069 http://dx.doi.org/10.1073/pnas.2209990120 |