SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to down-regulate MHC-I surface expression

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Major histocompatibility complex class I (MHC-I) molecules, which are dimers of a glycosylated polymorphic transmembrane heavy chain and the small-protein β(2)-microglobulin (β(2)m), bind peptides in the endoplasmic reticulum that are generated by the cytosolic turnover of cellular proteins. In viru...

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Detalles Bibliográficos
Autores principales: Arshad, Najla, Laurent-Rolle, Maudry, Ahmed, Wesam S., Hsu, Jack Chun-Chieh, Mitchell, Susan M., Pawlak, Joanna, Sengupta, Debrup, Biswas, Kabir H., Cresswell, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910621/
https://www.ncbi.nlm.nih.gov/pubmed/36574644
http://dx.doi.org/10.1073/pnas.2208525120
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