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Gain-of-function mutations in Trim71 linked to congenital hydrocephalus
The genetic basis of congenital hydrocephalus is only partially understood. A new study in PLOS Biology reports a potential gain-of-function pathological mechanism of congenital hydrocephalus in mouse embryonic stem cells that involves Wnt–β-catenin signaling pathway regulation.
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910648/ https://www.ncbi.nlm.nih.gov/pubmed/36757939 http://dx.doi.org/10.1371/journal.pbio.3001993 |