Different congenital hydrocephalus–associated mutations in Trim71 impair stem cell differentiation via distinct gain-of-function mechanisms

Congenital hydrocephalus (CH) is a common neurological disorder affecting many newborns. Imbalanced neurogenesis is a major cause of CH. Multiple CH-associated mutations are within the RNA-binding domain of Trim71, a conserved, stem cell–specific RNA-binding protein. How these mutations alter stem c...

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Detalles Bibliográficos
Autores principales: Liu, Qiuying, Novak, Mariah K., Pepin, Rachel M., Maschhoff, Katharine R., Hu, Wenqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910693/
https://www.ncbi.nlm.nih.gov/pubmed/36757932
http://dx.doi.org/10.1371/journal.pbio.3001947

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910693/
https://www.ncbi.nlm.nih.gov/pubmed/36757932
http://dx.doi.org/10.1371/journal.pbio.3001947

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