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Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm
BACKGROUND/OBJECTIVE: To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liver resection (LR). METHODS: This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910699/ https://www.ncbi.nlm.nih.gov/pubmed/36758025 http://dx.doi.org/10.1371/journal.pone.0281154 |
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author | Li, Wei-Feng Liu, Yueh-Wei Wang, Chih-Chi Yong, Chee-Chien Lin, Chih-Che Yen, Yi-Hao |
author_facet | Li, Wei-Feng Liu, Yueh-Wei Wang, Chih-Chi Yong, Chee-Chien Lin, Chih-Che Yen, Yi-Hao |
author_sort | Li, Wei-Feng |
collection | PubMed |
description | BACKGROUND/OBJECTIVE: To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liver resection (LR). METHODS: This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. RESULTS: Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. CONCLUSION: The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort. |
format | Online Article Text |
id | pubmed-9910699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-99106992023-02-10 Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm Li, Wei-Feng Liu, Yueh-Wei Wang, Chih-Chi Yong, Chee-Chien Lin, Chih-Che Yen, Yi-Hao PLoS One Research Article BACKGROUND/OBJECTIVE: To determine the impact of microvascular invasion (MVI) on outcome in patients with solitary hepatocellular carcinoma (HCC) of ≤ 2 cm undergoing liver resection (LR). METHODS: This retrospective study enrolled consecutive patients between 2007–2019 with newly diagnosed solitary HCC ≤ 2 cm who were undergoing LR at our institution. Overall survival (OS) and recurrent-free survival (RFS) were compared between patients with or without MVI. RESULTS: Of the 229 patients included in this study, 71 had MVI. The median follow-up period was 28.8 months (interquartile range: 13.5–70.1). Although the 90-day mortality rate was 0, 18 deaths occurred during the study, and the 5-year survival rate was 87.1%. Tumor recurrence occurred in 45 cases, and 5-year RFS was 71.9%. The presence or absence of MVI did not significantly affect the OS and RFS rates (log rank test, p = 0.10 and 0.38, respectively). In univariate and multivariate analysis, the presence of MVI was not associated with OS and RFS. CONCLUSION: The presence of MVI was not associated with OS and RFS in patients with solitary HCC ≤ 2 cm who underwent LR in this cohort. Public Library of Science 2023-02-09 /pmc/articles/PMC9910699/ /pubmed/36758025 http://dx.doi.org/10.1371/journal.pone.0281154 Text en © 2023 Li et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Li, Wei-Feng Liu, Yueh-Wei Wang, Chih-Chi Yong, Chee-Chien Lin, Chih-Che Yen, Yi-Hao Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
title | Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
title_full | Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
title_fullStr | Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
title_full_unstemmed | Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
title_short | Microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
title_sort | microscopic vascular invasion may not be associated with survival of patients undergoing resection for solitary hepatoma of ≤ 2 cm |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910699/ https://www.ncbi.nlm.nih.gov/pubmed/36758025 http://dx.doi.org/10.1371/journal.pone.0281154 |
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