Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs

Although ACE2 is the primary receptor for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection, a systematic assessment of host factors that regulate binding to SARS-CoV-2 spike protein has not been described. Here, we use whole-genome CRISPR activation to identify host factors con...

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Detalles Bibliográficos
Autores principales: Loo, Lipin, Waller, Matthew A., Moreno, Cesar L., Cole, Alexander J., Stella, Alberto Ospina, Pop, Oltin-Tiberiu, Jochum, Ann-Kristin, Ali, Omar Hasan, Denes, Christopher E., Hamoudi, Zina, Chung, Felicity, Aggarwal, Anupriya, Low, Jason K. K., Patel, Karishma, Siddiquee, Rezwan, Kang, Taeyoung, Mathivanan, Suresh, Mackay, Joel P., Jochum, Wolfram, Flatz, Lukas, Hesselson, Daniel, Turville, Stuart, Neely, G. Gregory
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910744/
https://www.ncbi.nlm.nih.gov/pubmed/36757924
http://dx.doi.org/10.1371/journal.pbio.3001967

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