The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

The severe acute respiratory syndrome associated coronavirus 2 (SARS-CoV-2) and SARS-CoV-1 accessory protein Orf3a colocalizes with markers of the plasma membrane, endocytic pathway, and Golgi apparatus. Some reports have led to annotation of both Orf3a proteins as viroporins. Here, we show that nei...

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Detalles Bibliográficos
Autores principales: Miller, Alexandria N, Houlihan, Patrick R, Matamala, Ella, Cabezas-Bratesco, Deny, Lee, Gi Young, Cristofori-Armstrong, Ben, Dilan, Tanya L, Sanchez-Martinez, Silvia, Matthies, Doreen, Yan, Rui, Yu, Zhiheng, Ren, Dejian, Brauchi, Sebastian E, Clapham, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910834/
https://www.ncbi.nlm.nih.gov/pubmed/36695574
http://dx.doi.org/10.7554/eLife.84477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9910834/
https://www.ncbi.nlm.nih.gov/pubmed/36695574
http://dx.doi.org/10.7554/eLife.84477

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