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Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma

Intradural extramedullary metastasis of renal cell carcinoma is exceedingly uncommon, and only 19 cases have been reported in the literature. It is thought to metastasize from the kidneys through venous networks or along nerves and may also spread from brain metastases through cerebrospinal fluid. W...

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Autores principales: Hassan, Omron, Gassie, Kelly, Goyal, Anshit, Foskey, Stephanie, Abode-Iyamah, Kingsley
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911312/
https://www.ncbi.nlm.nih.gov/pubmed/36788834
http://dx.doi.org/10.7759/cureus.33618
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author Hassan, Omron
Gassie, Kelly
Goyal, Anshit
Foskey, Stephanie
Abode-Iyamah, Kingsley
author_facet Hassan, Omron
Gassie, Kelly
Goyal, Anshit
Foskey, Stephanie
Abode-Iyamah, Kingsley
author_sort Hassan, Omron
collection PubMed
description Intradural extramedullary metastasis of renal cell carcinoma is exceedingly uncommon, and only 19 cases have been reported in the literature. It is thought to metastasize from the kidneys through venous networks or along nerves and may also spread from brain metastases through cerebrospinal fluid. We present a 52-year-old female, two years after a nephrectomy with myelopathic symptoms, who was found to have thoracic intradural extramedullary metastasis from renal cell carcinoma. The thoracic tumor was resected without any added deficit, but an additional brain mass was found on postoperative imaging. The present case and a literature review were discussed to explore considerations for neurosurgical intervention in similar patients, evaluate surgical outcomes, and highlight current theories on routes of metastasis. Given the risk of neurological decline in patients with metastatic intradural renal cell carcinoma, surgical resection should be considered upon its discovery, and postoperative surveillance imaging is encouraged.
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spelling pubmed-99113122023-02-13 Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma Hassan, Omron Gassie, Kelly Goyal, Anshit Foskey, Stephanie Abode-Iyamah, Kingsley Cureus Radiation Oncology Intradural extramedullary metastasis of renal cell carcinoma is exceedingly uncommon, and only 19 cases have been reported in the literature. It is thought to metastasize from the kidneys through venous networks or along nerves and may also spread from brain metastases through cerebrospinal fluid. We present a 52-year-old female, two years after a nephrectomy with myelopathic symptoms, who was found to have thoracic intradural extramedullary metastasis from renal cell carcinoma. The thoracic tumor was resected without any added deficit, but an additional brain mass was found on postoperative imaging. The present case and a literature review were discussed to explore considerations for neurosurgical intervention in similar patients, evaluate surgical outcomes, and highlight current theories on routes of metastasis. Given the risk of neurological decline in patients with metastatic intradural renal cell carcinoma, surgical resection should be considered upon its discovery, and postoperative surveillance imaging is encouraged. Cureus 2023-01-10 /pmc/articles/PMC9911312/ /pubmed/36788834 http://dx.doi.org/10.7759/cureus.33618 Text en Copyright © 2023, Hassan et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Radiation Oncology
Hassan, Omron
Gassie, Kelly
Goyal, Anshit
Foskey, Stephanie
Abode-Iyamah, Kingsley
Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma
title Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma
title_full Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma
title_fullStr Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma
title_full_unstemmed Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma
title_short Clinical Features and Neurosurgical Management of Metastatic Intradural Extramedullary Renal Cell Carcinoma
title_sort clinical features and neurosurgical management of metastatic intradural extramedullary renal cell carcinoma
topic Radiation Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911312/
https://www.ncbi.nlm.nih.gov/pubmed/36788834
http://dx.doi.org/10.7759/cureus.33618
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