1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model

Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative g...

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Autores principales: Ono, Masafumi, Kageyama, Shigetaka, O’Leary, Neil, El-Kurdi, Mohammed S., Reinöhl, Jochen, Solien, Eric, Bianco, Richard W., Doss, Mirko, Meuris, Bart, Virmani, Renu, Cox, Martijn, Onuma, Yoshinobu, Serruys, Patrick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911320/
https://www.ncbi.nlm.nih.gov/pubmed/36777172
http://dx.doi.org/10.1016/j.jacbts.2022.06.021
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author Ono, Masafumi
Kageyama, Shigetaka
O’Leary, Neil
El-Kurdi, Mohammed S.
Reinöhl, Jochen
Solien, Eric
Bianco, Richard W.
Doss, Mirko
Meuris, Bart
Virmani, Renu
Cox, Martijn
Onuma, Yoshinobu
Serruys, Patrick W.
author_facet Ono, Masafumi
Kageyama, Shigetaka
O’Leary, Neil
El-Kurdi, Mohammed S.
Reinöhl, Jochen
Solien, Eric
Bianco, Richard W.
Doss, Mirko
Meuris, Bart
Virmani, Renu
Cox, Martijn
Onuma, Yoshinobu
Serruys, Patrick W.
author_sort Ono, Masafumi
collection PubMed
description Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG.
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spelling pubmed-99113202023-02-11 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model Ono, Masafumi Kageyama, Shigetaka O’Leary, Neil El-Kurdi, Mohammed S. Reinöhl, Jochen Solien, Eric Bianco, Richard W. Doss, Mirko Meuris, Bart Virmani, Renu Cox, Martijn Onuma, Yoshinobu Serruys, Patrick W. JACC Basic Transl Sci Original Research - Preclinical Many attempts have been made to inhibit or counteract saphenous vein graft (SVG) failure modes; however, only external support for SVGs has gained momentum in clinical utility. This study revealed the feasibility of implantation, and showed good patency out to 12 months of the novel biorestorative graft, in a challenging ovine coronary artery bypass graft model. This finding could trigger the first-in-man trial of using the novel material instead of SVG. We believe that, eventually, this novel biorestorative bypass graft can be one of the options for coronary artery bypass graft patients who have difficulty harvesting SVG. Elsevier 2022-11-09 /pmc/articles/PMC9911320/ /pubmed/36777172 http://dx.doi.org/10.1016/j.jacbts.2022.06.021 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Preclinical
Ono, Masafumi
Kageyama, Shigetaka
O’Leary, Neil
El-Kurdi, Mohammed S.
Reinöhl, Jochen
Solien, Eric
Bianco, Richard W.
Doss, Mirko
Meuris, Bart
Virmani, Renu
Cox, Martijn
Onuma, Yoshinobu
Serruys, Patrick W.
1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model
title 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model
title_full 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model
title_fullStr 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model
title_full_unstemmed 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model
title_short 1-Year Patency of Biorestorative Polymeric Coronary Artery Bypass Grafts in an Ovine Model
title_sort 1-year patency of biorestorative polymeric coronary artery bypass grafts in an ovine model
topic Original Research - Preclinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911320/
https://www.ncbi.nlm.nih.gov/pubmed/36777172
http://dx.doi.org/10.1016/j.jacbts.2022.06.021
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