Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury

Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen rec...

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Detalles Bibliográficos
Autores principales: Liu, Pang-Yen, Fukuma, Nobuaki, Hiroi, Yukio, Kunita, Akiko, Tokiwa, Hiroyuki, Ueda, Kazutaka, Kariya, Taro, Numata, Genri, Adachi, Yusuke, Tajima, Miyu, Toyoda, Masayuki, Li, Yuxin, Noma, Kensuke, Harada, Mutsuo, Toko, Haruhiro, Ushiku, Tetsuo, Kanai, Yoshimitsu, Takimoto, Eiki, Liao, James K., Komuro, Issei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911321/
https://www.ncbi.nlm.nih.gov/pubmed/36777173
http://dx.doi.org/10.1016/j.jacbts.2022.07.001
Descripción
Sumario:Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen receptor-α non-nuclear signaling in the vasculoprotective effects of estrogen.

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