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Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury
Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen rec...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911321/ https://www.ncbi.nlm.nih.gov/pubmed/36777173 http://dx.doi.org/10.1016/j.jacbts.2022.07.001 |
| _version_ | 1784884967971487744 |
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| author | Liu, Pang-Yen Fukuma, Nobuaki Hiroi, Yukio Kunita, Akiko Tokiwa, Hiroyuki Ueda, Kazutaka Kariya, Taro Numata, Genri Adachi, Yusuke Tajima, Miyu Toyoda, Masayuki Li, Yuxin Noma, Kensuke Harada, Mutsuo Toko, Haruhiro Ushiku, Tetsuo Kanai, Yoshimitsu Takimoto, Eiki Liao, James K. Komuro, Issei |
| author_facet | Liu, Pang-Yen Fukuma, Nobuaki Hiroi, Yukio Kunita, Akiko Tokiwa, Hiroyuki Ueda, Kazutaka Kariya, Taro Numata, Genri Adachi, Yusuke Tajima, Miyu Toyoda, Masayuki Li, Yuxin Noma, Kensuke Harada, Mutsuo Toko, Haruhiro Ushiku, Tetsuo Kanai, Yoshimitsu Takimoto, Eiki Liao, James K. Komuro, Issei |
| author_sort | Liu, Pang-Yen |
| collection | PubMed |
| description | Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen receptor-α non-nuclear signaling in the vasculoprotective effects of estrogen. |
| format | Online Article Text |
| id | pubmed-9911321 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99113212023-02-11 Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury Liu, Pang-Yen Fukuma, Nobuaki Hiroi, Yukio Kunita, Akiko Tokiwa, Hiroyuki Ueda, Kazutaka Kariya, Taro Numata, Genri Adachi, Yusuke Tajima, Miyu Toyoda, Masayuki Li, Yuxin Noma, Kensuke Harada, Mutsuo Toko, Haruhiro Ushiku, Tetsuo Kanai, Yoshimitsu Takimoto, Eiki Liao, James K. Komuro, Issei JACC Basic Transl Sci Original Research - Preclinical Using the Cre-loxP system, we generated the first mouse model in which estrogen receptor-α non-nuclear signaling was inactivated in endothelial cells. Estrogen protection against mechanical vascular injury was impaired in this model. This result indicates the pivotal role of endothelial estrogen receptor-α non-nuclear signaling in the vasculoprotective effects of estrogen. Elsevier 2022-11-16 /pmc/articles/PMC9911321/ /pubmed/36777173 http://dx.doi.org/10.1016/j.jacbts.2022.07.001 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| spellingShingle | Original Research - Preclinical Liu, Pang-Yen Fukuma, Nobuaki Hiroi, Yukio Kunita, Akiko Tokiwa, Hiroyuki Ueda, Kazutaka Kariya, Taro Numata, Genri Adachi, Yusuke Tajima, Miyu Toyoda, Masayuki Li, Yuxin Noma, Kensuke Harada, Mutsuo Toko, Haruhiro Ushiku, Tetsuo Kanai, Yoshimitsu Takimoto, Eiki Liao, James K. Komuro, Issei Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury |
| title | Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury |
| title_full | Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury |
| title_fullStr | Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury |
| title_full_unstemmed | Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury |
| title_short | Tie2-Cre–Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury |
| title_sort | tie2-cre–induced inactivation of non-nuclear estrogen receptor-α signaling abrogates estrogen protection against vascular injury |
| topic | Original Research - Preclinical |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911321/ https://www.ncbi.nlm.nih.gov/pubmed/36777173 http://dx.doi.org/10.1016/j.jacbts.2022.07.001 |
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