Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation

Traditional anatomically guided ablation and attempts to perform electrogram-guided atrial fibrillation (AF) ablation (CFAE, DF, and FIRM) have not been shown to be sufficient treatment for persistent AF. Using biatrial high-density electrophysiologic mapping in a canine rapid atrial pacing model of...

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Autores principales: Yoo, Shin, Rottmann, Markus, Ng, Jason, Johnson, David, Shanab, Bassel, Pfenniger, Anna, Geist, Gail Elizabeth, Mandava, Suman, Burrell, Amy, Zhang, Wenwei, Wasserstrom, J. Andrew, Knight, Bradley P., Passman, Rod, Goldberger, Jeffrey J., Arora, Rishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911322/
https://www.ncbi.nlm.nih.gov/pubmed/36777167
http://dx.doi.org/10.1016/j.jacbts.2022.07.011
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author Yoo, Shin
Rottmann, Markus
Ng, Jason
Johnson, David
Shanab, Bassel
Pfenniger, Anna
Geist, Gail Elizabeth
Mandava, Suman
Burrell, Amy
Zhang, Wenwei
Wasserstrom, J. Andrew
Knight, Bradley P.
Passman, Rod
Goldberger, Jeffrey J.
Arora, Rishi
author_facet Yoo, Shin
Rottmann, Markus
Ng, Jason
Johnson, David
Shanab, Bassel
Pfenniger, Anna
Geist, Gail Elizabeth
Mandava, Suman
Burrell, Amy
Zhang, Wenwei
Wasserstrom, J. Andrew
Knight, Bradley P.
Passman, Rod
Goldberger, Jeffrey J.
Arora, Rishi
author_sort Yoo, Shin
collection PubMed
description Traditional anatomically guided ablation and attempts to perform electrogram-guided atrial fibrillation (AF) ablation (CFAE, DF, and FIRM) have not been shown to be sufficient treatment for persistent AF. Using biatrial high-density electrophysiologic mapping in a canine rapid atrial pacing model of AF, we systematically investigated the relationship of electrogram morphology recurrence (EMR) (Rec% and CL(R)) with established AF electrogram parameters and tissue characteristics. Rec% correlates with stability of rotational activity and with the spatial distribution of parasympathetic nerve fibers. These results have indicated that EMR may therefore be a viable therapeutic target in persistent AF.
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spelling pubmed-99113222023-02-11 Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation Yoo, Shin Rottmann, Markus Ng, Jason Johnson, David Shanab, Bassel Pfenniger, Anna Geist, Gail Elizabeth Mandava, Suman Burrell, Amy Zhang, Wenwei Wasserstrom, J. Andrew Knight, Bradley P. Passman, Rod Goldberger, Jeffrey J. Arora, Rishi JACC Basic Transl Sci Original Research - Preclinical Traditional anatomically guided ablation and attempts to perform electrogram-guided atrial fibrillation (AF) ablation (CFAE, DF, and FIRM) have not been shown to be sufficient treatment for persistent AF. Using biatrial high-density electrophysiologic mapping in a canine rapid atrial pacing model of AF, we systematically investigated the relationship of electrogram morphology recurrence (EMR) (Rec% and CL(R)) with established AF electrogram parameters and tissue characteristics. Rec% correlates with stability of rotational activity and with the spatial distribution of parasympathetic nerve fibers. These results have indicated that EMR may therefore be a viable therapeutic target in persistent AF. Elsevier 2022-11-23 /pmc/articles/PMC9911322/ /pubmed/36777167 http://dx.doi.org/10.1016/j.jacbts.2022.07.011 Text en © 2022 Published by Elsevier on behalf of the American College of Cardiology Foundation. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research - Preclinical
Yoo, Shin
Rottmann, Markus
Ng, Jason
Johnson, David
Shanab, Bassel
Pfenniger, Anna
Geist, Gail Elizabeth
Mandava, Suman
Burrell, Amy
Zhang, Wenwei
Wasserstrom, J. Andrew
Knight, Bradley P.
Passman, Rod
Goldberger, Jeffrey J.
Arora, Rishi
Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
title Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
title_full Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
title_fullStr Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
title_full_unstemmed Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
title_short Regions of Highly Recurrent Electrogram Morphology With Low Cycle Length Reflect Substrate for Atrial Fibrillation
title_sort regions of highly recurrent electrogram morphology with low cycle length reflect substrate for atrial fibrillation
topic Original Research - Preclinical
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911322/
https://www.ncbi.nlm.nih.gov/pubmed/36777167
http://dx.doi.org/10.1016/j.jacbts.2022.07.011
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