Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine

MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardi...

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Detalles Bibliográficos
Autores principales: Bruce, Christopher G., Khan, Jaffar M., Rogers, Toby, Yildirim, D. Korel, Jaimes, Andrea E., Seemann, Felicia, Chen, Marcus Y., O’Brien, Kendall, Herzka, Daniel A., Schenke, William H., Eckhaus, Michael A., Potersnak, Amanda G., Campbell-Washburn, Adrienne, Babaliaros, Vasilis C., Greenbaum, Adam B., Lederman, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911325/
https://www.ncbi.nlm.nih.gov/pubmed/36777171
http://dx.doi.org/10.1016/j.jacbts.2022.07.002
Descripción
Sumario:MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance. MIRTH may help treat dilated cardiomyopathy. Clinical investigation is warranted.

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