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Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine
MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardi...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911325/ https://www.ncbi.nlm.nih.gov/pubmed/36777171 http://dx.doi.org/10.1016/j.jacbts.2022.07.002 |
| _version_ | 1784884968984412160 |
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| author | Bruce, Christopher G. Khan, Jaffar M. Rogers, Toby Yildirim, D. Korel Jaimes, Andrea E. Seemann, Felicia Chen, Marcus Y. O’Brien, Kendall Herzka, Daniel A. Schenke, William H. Eckhaus, Michael A. Potersnak, Amanda G. Campbell-Washburn, Adrienne Babaliaros, Vasilis C. Greenbaum, Adam B. Lederman, Robert J. |
| author_facet | Bruce, Christopher G. Khan, Jaffar M. Rogers, Toby Yildirim, D. Korel Jaimes, Andrea E. Seemann, Felicia Chen, Marcus Y. O’Brien, Kendall Herzka, Daniel A. Schenke, William H. Eckhaus, Michael A. Potersnak, Amanda G. Campbell-Washburn, Adrienne Babaliaros, Vasilis C. Greenbaum, Adam B. Lederman, Robert J. |
| author_sort | Bruce, Christopher G. |
| collection | PubMed |
| description | MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance. MIRTH may help treat dilated cardiomyopathy. Clinical investigation is warranted. |
| format | Online Article Text |
| id | pubmed-9911325 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99113252023-02-11 Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine Bruce, Christopher G. Khan, Jaffar M. Rogers, Toby Yildirim, D. Korel Jaimes, Andrea E. Seemann, Felicia Chen, Marcus Y. O’Brien, Kendall Herzka, Daniel A. Schenke, William H. Eckhaus, Michael A. Potersnak, Amanda G. Campbell-Washburn, Adrienne Babaliaros, Vasilis C. Greenbaum, Adam B. Lederman, Robert J. JACC Basic Transl Sci Original Research - Preclinical MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) is a transcatheter ventricular remodeling procedure. A transvenous tension element is placed within the walls of the beating left ventricle and shortened to narrow chamber dimensions. MIRTH uses 2 new techniques: controlled intramyocardial guidewire navigation and EDEN (Electrocardiographic Radial Depth Navigation). MIRTH caused a sustained reduction in chamber dimensions in healthy swine. Midventricular implants approximated papillary muscles. MIRTH shortening improved myocardial contractility in cardiomyopathy in a dose-dependent manner up to a threshold beyond which additional shortening reduced performance. MIRTH may help treat dilated cardiomyopathy. Clinical investigation is warranted. Elsevier 2022-11-09 /pmc/articles/PMC9911325/ /pubmed/36777171 http://dx.doi.org/10.1016/j.jacbts.2022.07.002 Text en https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Original Research - Preclinical Bruce, Christopher G. Khan, Jaffar M. Rogers, Toby Yildirim, D. Korel Jaimes, Andrea E. Seemann, Felicia Chen, Marcus Y. O’Brien, Kendall Herzka, Daniel A. Schenke, William H. Eckhaus, Michael A. Potersnak, Amanda G. Campbell-Washburn, Adrienne Babaliaros, Vasilis C. Greenbaum, Adam B. Lederman, Robert J. Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine |
| title | Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine |
| title_full | Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine |
| title_fullStr | Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine |
| title_full_unstemmed | Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine |
| title_short | Reshaping the Ventricle From Within: MIRTH (Myocardial Intramural Remodeling by Transvenous Tether) Ventriculoplasty in Swine |
| title_sort | reshaping the ventricle from within: mirth (myocardial intramural remodeling by transvenous tether) ventriculoplasty in swine |
| topic | Original Research - Preclinical |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911325/ https://www.ncbi.nlm.nih.gov/pubmed/36777171 http://dx.doi.org/10.1016/j.jacbts.2022.07.002 |
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