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Opportunities and barriers to translating the hibernation phenotype for neurocritical care

Targeted temperature management (TTM) is standard of care for neonatal hypoxic ischemic encephalopathy (HIE). Prevention of fever, not excluding cooling core body temperature to 33°C, is standard of care for brain injury post cardiac arrest. Although TTM is beneficial, HIE and cardiac arrest still c...

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Autores principales: Drew, Kelly L., Bhowmick, Saurav, Laughlin, Bernard W., Goropashnaya, Anna V., Tøien, Øivind, Sugiura, M. Hoshi, Wong, Ardy, Pourrezaei, Kambiz, Barati, Zeinab, Chen, Chao-Yin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911456/
https://www.ncbi.nlm.nih.gov/pubmed/36779060
http://dx.doi.org/10.3389/fneur.2023.1009718
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author Drew, Kelly L.
Bhowmick, Saurav
Laughlin, Bernard W.
Goropashnaya, Anna V.
Tøien, Øivind
Sugiura, M. Hoshi
Wong, Ardy
Pourrezaei, Kambiz
Barati, Zeinab
Chen, Chao-Yin
author_facet Drew, Kelly L.
Bhowmick, Saurav
Laughlin, Bernard W.
Goropashnaya, Anna V.
Tøien, Øivind
Sugiura, M. Hoshi
Wong, Ardy
Pourrezaei, Kambiz
Barati, Zeinab
Chen, Chao-Yin
author_sort Drew, Kelly L.
collection PubMed
description Targeted temperature management (TTM) is standard of care for neonatal hypoxic ischemic encephalopathy (HIE). Prevention of fever, not excluding cooling core body temperature to 33°C, is standard of care for brain injury post cardiac arrest. Although TTM is beneficial, HIE and cardiac arrest still carry significant risk of death and severe disability. Mammalian hibernation is a gold standard of neuroprotective metabolic suppression, that if better understood might make TTM more accessible, improve efficacy of TTM and identify adjunctive therapies to protect and regenerate neurons after hypoxic ischemia brain injury. Hibernating species tolerate cerebral ischemia/reperfusion better than humans and better than other models of cerebral ischemia tolerance. Such tolerance limits risk of transitions into and out of hibernation torpor and suggests that a barrier to translate hibernation torpor may be human vulnerability to these transitions. At the same time, understanding how hibernating mammals protect their brains is an opportunity to identify adjunctive therapies for TTM. Here we summarize what is known about the hemodynamics of hibernation and how the hibernating brain resists injury to identify opportunities to translate these mechanisms for neurocritical care.
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spelling pubmed-99114562023-02-11 Opportunities and barriers to translating the hibernation phenotype for neurocritical care Drew, Kelly L. Bhowmick, Saurav Laughlin, Bernard W. Goropashnaya, Anna V. Tøien, Øivind Sugiura, M. Hoshi Wong, Ardy Pourrezaei, Kambiz Barati, Zeinab Chen, Chao-Yin Front Neurol Neurology Targeted temperature management (TTM) is standard of care for neonatal hypoxic ischemic encephalopathy (HIE). Prevention of fever, not excluding cooling core body temperature to 33°C, is standard of care for brain injury post cardiac arrest. Although TTM is beneficial, HIE and cardiac arrest still carry significant risk of death and severe disability. Mammalian hibernation is a gold standard of neuroprotective metabolic suppression, that if better understood might make TTM more accessible, improve efficacy of TTM and identify adjunctive therapies to protect and regenerate neurons after hypoxic ischemia brain injury. Hibernating species tolerate cerebral ischemia/reperfusion better than humans and better than other models of cerebral ischemia tolerance. Such tolerance limits risk of transitions into and out of hibernation torpor and suggests that a barrier to translate hibernation torpor may be human vulnerability to these transitions. At the same time, understanding how hibernating mammals protect their brains is an opportunity to identify adjunctive therapies for TTM. Here we summarize what is known about the hemodynamics of hibernation and how the hibernating brain resists injury to identify opportunities to translate these mechanisms for neurocritical care. Frontiers Media S.A. 2023-01-27 /pmc/articles/PMC9911456/ /pubmed/36779060 http://dx.doi.org/10.3389/fneur.2023.1009718 Text en Copyright © 2023 Drew, Bhowmick, Laughlin, Goropashnaya, Tøien, Sugiura, Wong, Pourrezaei, Barati and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Drew, Kelly L.
Bhowmick, Saurav
Laughlin, Bernard W.
Goropashnaya, Anna V.
Tøien, Øivind
Sugiura, M. Hoshi
Wong, Ardy
Pourrezaei, Kambiz
Barati, Zeinab
Chen, Chao-Yin
Opportunities and barriers to translating the hibernation phenotype for neurocritical care
title Opportunities and barriers to translating the hibernation phenotype for neurocritical care
title_full Opportunities and barriers to translating the hibernation phenotype for neurocritical care
title_fullStr Opportunities and barriers to translating the hibernation phenotype for neurocritical care
title_full_unstemmed Opportunities and barriers to translating the hibernation phenotype for neurocritical care
title_short Opportunities and barriers to translating the hibernation phenotype for neurocritical care
title_sort opportunities and barriers to translating the hibernation phenotype for neurocritical care
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911456/
https://www.ncbi.nlm.nih.gov/pubmed/36779060
http://dx.doi.org/10.3389/fneur.2023.1009718
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