Cargando…

The association between serum complement C3a and severity in patients with community-acquired pneumonia

BACKGROUND: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of this study was to analyze the association of serum complement C3a with CAP severit...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Zheng, Hou, Xue-Feng, Feng, Chun-Mei, Zheng, Ling, Xu, De-Xiang, Zhao, Hui, Fu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911530/
https://www.ncbi.nlm.nih.gov/pubmed/36776834
http://dx.doi.org/10.3389/fimmu.2023.1034233
_version_ 1784885008820862976
author Xu, Zheng
Hou, Xue-Feng
Feng, Chun-Mei
Zheng, Ling
Xu, De-Xiang
Zhao, Hui
Fu, Lin
author_facet Xu, Zheng
Hou, Xue-Feng
Feng, Chun-Mei
Zheng, Ling
Xu, De-Xiang
Zhao, Hui
Fu, Lin
author_sort Xu, Zheng
collection PubMed
description BACKGROUND: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of this study was to analyze the association of serum complement C3a with CAP severity scores based on a cross-sectional study. METHODS: All 190 CAP patients and 95 control subjects were enrolled. Demographic information and clinical data were extracted. Peripheral blood samples were collected on admission. RESULTS: Serum complement C3a on admission was elevated in CAP patients compared with healthy subjects. The level of complement C3a was gradually elevated in parallel with CAP severity scores (CURB-65, CRB-65, PSI, SMART-COP, and CURXO). Complement C3a was positively correlated with blood routine parameters, renal function markers, and inflammatory cytokines in CAP patients. Furthermore, multivariate linear and logistic regression models found that serum complement C3a on admission was positively associated with CAP severity scores. Mechanistic research suggested that complement system inhibition alleviated Streptococcus pneumoniae-induced upregulation of IL-1β, TNF-α, IL-6, and CRP in MLE-12 cells. CONCLUSIONS: Serum complement C3a on admission is positively associated with the severity of CAP patients. Inhibiting complement system attenuates S. pneumoniae-elevated secretion of inflammatory cytokines in pulmonary epithelial cells, indicating that complement C3a is involved in the pathophysiology of CAP. Serum complement C3a may serve as an earlier diagnostic biomarker for CAP.
format Online
Article
Text
id pubmed-9911530
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-99115302023-02-11 The association between serum complement C3a and severity in patients with community-acquired pneumonia Xu, Zheng Hou, Xue-Feng Feng, Chun-Mei Zheng, Ling Xu, De-Xiang Zhao, Hui Fu, Lin Front Immunol Immunology BACKGROUND: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of this study was to analyze the association of serum complement C3a with CAP severity scores based on a cross-sectional study. METHODS: All 190 CAP patients and 95 control subjects were enrolled. Demographic information and clinical data were extracted. Peripheral blood samples were collected on admission. RESULTS: Serum complement C3a on admission was elevated in CAP patients compared with healthy subjects. The level of complement C3a was gradually elevated in parallel with CAP severity scores (CURB-65, CRB-65, PSI, SMART-COP, and CURXO). Complement C3a was positively correlated with blood routine parameters, renal function markers, and inflammatory cytokines in CAP patients. Furthermore, multivariate linear and logistic regression models found that serum complement C3a on admission was positively associated with CAP severity scores. Mechanistic research suggested that complement system inhibition alleviated Streptococcus pneumoniae-induced upregulation of IL-1β, TNF-α, IL-6, and CRP in MLE-12 cells. CONCLUSIONS: Serum complement C3a on admission is positively associated with the severity of CAP patients. Inhibiting complement system attenuates S. pneumoniae-elevated secretion of inflammatory cytokines in pulmonary epithelial cells, indicating that complement C3a is involved in the pathophysiology of CAP. Serum complement C3a may serve as an earlier diagnostic biomarker for CAP. Frontiers Media S.A. 2023-01-27 /pmc/articles/PMC9911530/ /pubmed/36776834 http://dx.doi.org/10.3389/fimmu.2023.1034233 Text en Copyright © 2023 Xu, Hou, Feng, Zheng, Xu, Zhao and Fu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Xu, Zheng
Hou, Xue-Feng
Feng, Chun-Mei
Zheng, Ling
Xu, De-Xiang
Zhao, Hui
Fu, Lin
The association between serum complement C3a and severity in patients with community-acquired pneumonia
title The association between serum complement C3a and severity in patients with community-acquired pneumonia
title_full The association between serum complement C3a and severity in patients with community-acquired pneumonia
title_fullStr The association between serum complement C3a and severity in patients with community-acquired pneumonia
title_full_unstemmed The association between serum complement C3a and severity in patients with community-acquired pneumonia
title_short The association between serum complement C3a and severity in patients with community-acquired pneumonia
title_sort association between serum complement c3a and severity in patients with community-acquired pneumonia
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911530/
https://www.ncbi.nlm.nih.gov/pubmed/36776834
http://dx.doi.org/10.3389/fimmu.2023.1034233
work_keys_str_mv AT xuzheng theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT houxuefeng theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT fengchunmei theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT zhengling theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT xudexiang theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT zhaohui theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT fulin theassociationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT xuzheng associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT houxuefeng associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT fengchunmei associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT zhengling associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT xudexiang associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT zhaohui associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia
AT fulin associationbetweenserumcomplementc3aandseverityinpatientswithcommunityacquiredpneumonia