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The association between serum complement C3a and severity in patients with community-acquired pneumonia
BACKGROUND: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of this study was to analyze the association of serum complement C3a with CAP severit...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911530/ https://www.ncbi.nlm.nih.gov/pubmed/36776834 http://dx.doi.org/10.3389/fimmu.2023.1034233 |
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author | Xu, Zheng Hou, Xue-Feng Feng, Chun-Mei Zheng, Ling Xu, De-Xiang Zhao, Hui Fu, Lin |
author_facet | Xu, Zheng Hou, Xue-Feng Feng, Chun-Mei Zheng, Ling Xu, De-Xiang Zhao, Hui Fu, Lin |
author_sort | Xu, Zheng |
collection | PubMed |
description | BACKGROUND: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of this study was to analyze the association of serum complement C3a with CAP severity scores based on a cross-sectional study. METHODS: All 190 CAP patients and 95 control subjects were enrolled. Demographic information and clinical data were extracted. Peripheral blood samples were collected on admission. RESULTS: Serum complement C3a on admission was elevated in CAP patients compared with healthy subjects. The level of complement C3a was gradually elevated in parallel with CAP severity scores (CURB-65, CRB-65, PSI, SMART-COP, and CURXO). Complement C3a was positively correlated with blood routine parameters, renal function markers, and inflammatory cytokines in CAP patients. Furthermore, multivariate linear and logistic regression models found that serum complement C3a on admission was positively associated with CAP severity scores. Mechanistic research suggested that complement system inhibition alleviated Streptococcus pneumoniae-induced upregulation of IL-1β, TNF-α, IL-6, and CRP in MLE-12 cells. CONCLUSIONS: Serum complement C3a on admission is positively associated with the severity of CAP patients. Inhibiting complement system attenuates S. pneumoniae-elevated secretion of inflammatory cytokines in pulmonary epithelial cells, indicating that complement C3a is involved in the pathophysiology of CAP. Serum complement C3a may serve as an earlier diagnostic biomarker for CAP. |
format | Online Article Text |
id | pubmed-9911530 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99115302023-02-11 The association between serum complement C3a and severity in patients with community-acquired pneumonia Xu, Zheng Hou, Xue-Feng Feng, Chun-Mei Zheng, Ling Xu, De-Xiang Zhao, Hui Fu, Lin Front Immunol Immunology BACKGROUND: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was obscure. The goal of this study was to analyze the association of serum complement C3a with CAP severity scores based on a cross-sectional study. METHODS: All 190 CAP patients and 95 control subjects were enrolled. Demographic information and clinical data were extracted. Peripheral blood samples were collected on admission. RESULTS: Serum complement C3a on admission was elevated in CAP patients compared with healthy subjects. The level of complement C3a was gradually elevated in parallel with CAP severity scores (CURB-65, CRB-65, PSI, SMART-COP, and CURXO). Complement C3a was positively correlated with blood routine parameters, renal function markers, and inflammatory cytokines in CAP patients. Furthermore, multivariate linear and logistic regression models found that serum complement C3a on admission was positively associated with CAP severity scores. Mechanistic research suggested that complement system inhibition alleviated Streptococcus pneumoniae-induced upregulation of IL-1β, TNF-α, IL-6, and CRP in MLE-12 cells. CONCLUSIONS: Serum complement C3a on admission is positively associated with the severity of CAP patients. Inhibiting complement system attenuates S. pneumoniae-elevated secretion of inflammatory cytokines in pulmonary epithelial cells, indicating that complement C3a is involved in the pathophysiology of CAP. Serum complement C3a may serve as an earlier diagnostic biomarker for CAP. Frontiers Media S.A. 2023-01-27 /pmc/articles/PMC9911530/ /pubmed/36776834 http://dx.doi.org/10.3389/fimmu.2023.1034233 Text en Copyright © 2023 Xu, Hou, Feng, Zheng, Xu, Zhao and Fu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Xu, Zheng Hou, Xue-Feng Feng, Chun-Mei Zheng, Ling Xu, De-Xiang Zhao, Hui Fu, Lin The association between serum complement C3a and severity in patients with community-acquired pneumonia |
title | The association between serum complement C3a and severity in patients with community-acquired pneumonia |
title_full | The association between serum complement C3a and severity in patients with community-acquired pneumonia |
title_fullStr | The association between serum complement C3a and severity in patients with community-acquired pneumonia |
title_full_unstemmed | The association between serum complement C3a and severity in patients with community-acquired pneumonia |
title_short | The association between serum complement C3a and severity in patients with community-acquired pneumonia |
title_sort | association between serum complement c3a and severity in patients with community-acquired pneumonia |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911530/ https://www.ncbi.nlm.nih.gov/pubmed/36776834 http://dx.doi.org/10.3389/fimmu.2023.1034233 |
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