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Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets

Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo Kruskal-Wallis power studies were compared with measured power, a Monte-Carlo ANOVA equivalent and with an analytical method, with or without normalization, using four simulated runs, e...

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Autores principales: Clark, Jeremy S. C., Kulig, Piotr, Podsiadło, Konrad, Rydzewska, Kamila, Arabski, Krzysztof, Białecka, Monika, Safranow, Krzysztof, Ciechanowicz, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911609/
https://www.ncbi.nlm.nih.gov/pubmed/36759640
http://dx.doi.org/10.1038/s41598-023-29308-2
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author Clark, Jeremy S. C.
Kulig, Piotr
Podsiadło, Konrad
Rydzewska, Kamila
Arabski, Krzysztof
Białecka, Monika
Safranow, Krzysztof
Ciechanowicz, Andrzej
author_facet Clark, Jeremy S. C.
Kulig, Piotr
Podsiadło, Konrad
Rydzewska, Kamila
Arabski, Krzysztof
Białecka, Monika
Safranow, Krzysztof
Ciechanowicz, Andrzej
author_sort Clark, Jeremy S. C.
collection PubMed
description Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo Kruskal-Wallis power studies were compared with measured power, a Monte-Carlo ANOVA equivalent and with an analytical method, with or without normalization, using four simulated runs, each with 60–100 populations (each population with N = 30,000 from a set of Pearson-type ranges): random selection gave 6300 samples analyzed for predictive power. Three medical-study datasets (Dialysis/systolic blood pressure; Diabetes/sleep-hours; Marital-status/high-density-lipoprotein cholesterol) were also analyzed. In three from four simulated runs (run_one, run_one_relaxed, and run_three) with Pearson types pooled, Monte-Carlo Kruskal-Wallis gave predicted sample sizes significantly slightly lower than measured but more accurate than with ANOVA methods; the latter gave high sample-size predictions. Populations (run_one_relaxed) with ANOVA assumptions invalid gave Kruskal-Wallis predictions similar to those measured. In two from three medical studies, Kruskal-Wallis predictions (Dialysis: similar predictions; Marital: higher than measured) were more accurate than ANOVA (both higher than measured) but in one (Diabetes) the reverse was found (Kruskal-Wallis: lower; Monte-Carlo ANOVA: similar to measured). These preliminary studies appear to show that Monte-Carlo Kruskal-Wallis power studies, based on Bernstein fits, might perform better than ANOVA equivalents in many settings (and provide reasonable results when ANOVA cannot be used); and both Monte-Carlo methods appeared to be considerably more accurate than the analytical version analyzed.
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spelling pubmed-99116092023-02-11 Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets Clark, Jeremy S. C. Kulig, Piotr Podsiadło, Konrad Rydzewska, Kamila Arabski, Krzysztof Białecka, Monika Safranow, Krzysztof Ciechanowicz, Andrzej Sci Rep Article Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo Kruskal-Wallis power studies were compared with measured power, a Monte-Carlo ANOVA equivalent and with an analytical method, with or without normalization, using four simulated runs, each with 60–100 populations (each population with N = 30,000 from a set of Pearson-type ranges): random selection gave 6300 samples analyzed for predictive power. Three medical-study datasets (Dialysis/systolic blood pressure; Diabetes/sleep-hours; Marital-status/high-density-lipoprotein cholesterol) were also analyzed. In three from four simulated runs (run_one, run_one_relaxed, and run_three) with Pearson types pooled, Monte-Carlo Kruskal-Wallis gave predicted sample sizes significantly slightly lower than measured but more accurate than with ANOVA methods; the latter gave high sample-size predictions. Populations (run_one_relaxed) with ANOVA assumptions invalid gave Kruskal-Wallis predictions similar to those measured. In two from three medical studies, Kruskal-Wallis predictions (Dialysis: similar predictions; Marital: higher than measured) were more accurate than ANOVA (both higher than measured) but in one (Diabetes) the reverse was found (Kruskal-Wallis: lower; Monte-Carlo ANOVA: similar to measured). These preliminary studies appear to show that Monte-Carlo Kruskal-Wallis power studies, based on Bernstein fits, might perform better than ANOVA equivalents in many settings (and provide reasonable results when ANOVA cannot be used); and both Monte-Carlo methods appeared to be considerably more accurate than the analytical version analyzed. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9911609/ /pubmed/36759640 http://dx.doi.org/10.1038/s41598-023-29308-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Clark, Jeremy S. C.
Kulig, Piotr
Podsiadło, Konrad
Rydzewska, Kamila
Arabski, Krzysztof
Białecka, Monika
Safranow, Krzysztof
Ciechanowicz, Andrzej
Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
title Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
title_full Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
title_fullStr Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
title_full_unstemmed Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
title_short Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
title_sort empirical investigations into kruskal-wallis power studies utilizing bernstein fits, simulations and medical study datasets
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911609/
https://www.ncbi.nlm.nih.gov/pubmed/36759640
http://dx.doi.org/10.1038/s41598-023-29308-2
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