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Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets
Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo Kruskal-Wallis power studies were compared with measured power, a Monte-Carlo ANOVA equivalent and with an analytical method, with or without normalization, using four simulated runs, e...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911609/ https://www.ncbi.nlm.nih.gov/pubmed/36759640 http://dx.doi.org/10.1038/s41598-023-29308-2 |
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author | Clark, Jeremy S. C. Kulig, Piotr Podsiadło, Konrad Rydzewska, Kamila Arabski, Krzysztof Białecka, Monika Safranow, Krzysztof Ciechanowicz, Andrzej |
author_facet | Clark, Jeremy S. C. Kulig, Piotr Podsiadło, Konrad Rydzewska, Kamila Arabski, Krzysztof Białecka, Monika Safranow, Krzysztof Ciechanowicz, Andrzej |
author_sort | Clark, Jeremy S. C. |
collection | PubMed |
description | Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo Kruskal-Wallis power studies were compared with measured power, a Monte-Carlo ANOVA equivalent and with an analytical method, with or without normalization, using four simulated runs, each with 60–100 populations (each population with N = 30,000 from a set of Pearson-type ranges): random selection gave 6300 samples analyzed for predictive power. Three medical-study datasets (Dialysis/systolic blood pressure; Diabetes/sleep-hours; Marital-status/high-density-lipoprotein cholesterol) were also analyzed. In three from four simulated runs (run_one, run_one_relaxed, and run_three) with Pearson types pooled, Monte-Carlo Kruskal-Wallis gave predicted sample sizes significantly slightly lower than measured but more accurate than with ANOVA methods; the latter gave high sample-size predictions. Populations (run_one_relaxed) with ANOVA assumptions invalid gave Kruskal-Wallis predictions similar to those measured. In two from three medical studies, Kruskal-Wallis predictions (Dialysis: similar predictions; Marital: higher than measured) were more accurate than ANOVA (both higher than measured) but in one (Diabetes) the reverse was found (Kruskal-Wallis: lower; Monte-Carlo ANOVA: similar to measured). These preliminary studies appear to show that Monte-Carlo Kruskal-Wallis power studies, based on Bernstein fits, might perform better than ANOVA equivalents in many settings (and provide reasonable results when ANOVA cannot be used); and both Monte-Carlo methods appeared to be considerably more accurate than the analytical version analyzed. |
format | Online Article Text |
id | pubmed-9911609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99116092023-02-11 Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets Clark, Jeremy S. C. Kulig, Piotr Podsiadło, Konrad Rydzewska, Kamila Arabski, Krzysztof Białecka, Monika Safranow, Krzysztof Ciechanowicz, Andrzej Sci Rep Article Bernstein fits implemented into R allow another route for Kruskal-Wallis power-study tool development. Monte-Carlo Kruskal-Wallis power studies were compared with measured power, a Monte-Carlo ANOVA equivalent and with an analytical method, with or without normalization, using four simulated runs, each with 60–100 populations (each population with N = 30,000 from a set of Pearson-type ranges): random selection gave 6300 samples analyzed for predictive power. Three medical-study datasets (Dialysis/systolic blood pressure; Diabetes/sleep-hours; Marital-status/high-density-lipoprotein cholesterol) were also analyzed. In three from four simulated runs (run_one, run_one_relaxed, and run_three) with Pearson types pooled, Monte-Carlo Kruskal-Wallis gave predicted sample sizes significantly slightly lower than measured but more accurate than with ANOVA methods; the latter gave high sample-size predictions. Populations (run_one_relaxed) with ANOVA assumptions invalid gave Kruskal-Wallis predictions similar to those measured. In two from three medical studies, Kruskal-Wallis predictions (Dialysis: similar predictions; Marital: higher than measured) were more accurate than ANOVA (both higher than measured) but in one (Diabetes) the reverse was found (Kruskal-Wallis: lower; Monte-Carlo ANOVA: similar to measured). These preliminary studies appear to show that Monte-Carlo Kruskal-Wallis power studies, based on Bernstein fits, might perform better than ANOVA equivalents in many settings (and provide reasonable results when ANOVA cannot be used); and both Monte-Carlo methods appeared to be considerably more accurate than the analytical version analyzed. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9911609/ /pubmed/36759640 http://dx.doi.org/10.1038/s41598-023-29308-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Clark, Jeremy S. C. Kulig, Piotr Podsiadło, Konrad Rydzewska, Kamila Arabski, Krzysztof Białecka, Monika Safranow, Krzysztof Ciechanowicz, Andrzej Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets |
title | Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets |
title_full | Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets |
title_fullStr | Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets |
title_full_unstemmed | Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets |
title_short | Empirical investigations into Kruskal-Wallis power studies utilizing Bernstein fits, simulations and medical study datasets |
title_sort | empirical investigations into kruskal-wallis power studies utilizing bernstein fits, simulations and medical study datasets |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911609/ https://www.ncbi.nlm.nih.gov/pubmed/36759640 http://dx.doi.org/10.1038/s41598-023-29308-2 |
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