Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections

Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may include dextrous hand function. Although prior work has focused on the recovery at the person-level, the factors determining the recovery of individual muscles are poorly understood. Here, we investigate the mus...

Descripción completa

Detalles Bibliográficos
Autores principales: Balbinot, Gustavo, Li, Guijin, Kalsi-Ryan, Sukhvinder, Abel, Rainer, Maier, Doris, Kalke, Yorck-Bernhard, Weidner, Norbert, Rupp, Rüdiger, Schubert, Martin, Curt, Armin, Zariffa, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911610/
https://www.ncbi.nlm.nih.gov/pubmed/36759606
http://dx.doi.org/10.1038/s41467-023-36390-7
_version_ 1784885023463178240
author Balbinot, Gustavo
Li, Guijin
Kalsi-Ryan, Sukhvinder
Abel, Rainer
Maier, Doris
Kalke, Yorck-Bernhard
Weidner, Norbert
Rupp, Rüdiger
Schubert, Martin
Curt, Armin
Zariffa, Jose
author_facet Balbinot, Gustavo
Li, Guijin
Kalsi-Ryan, Sukhvinder
Abel, Rainer
Maier, Doris
Kalke, Yorck-Bernhard
Weidner, Norbert
Rupp, Rüdiger
Schubert, Martin
Curt, Armin
Zariffa, Jose
author_sort Balbinot, Gustavo
collection PubMed
description Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may include dextrous hand function. Although prior work has focused on the recovery at the person-level, the factors determining the recovery of individual muscles are poorly understood. Here, we investigate the muscle-specific recovery after cervical spinal cord injury in a retrospective analysis of 748 individuals from the European Multicenter Study about Spinal Cord Injury (NCT01571531). We show associations between corticospinal tract (CST) sparing and upper extremity recovery in SCI, which improves the prediction of hand muscle strength recovery. Our findings suggest that assessment strategies for muscle-specific motor recovery in acute spinal cord injury are improved by accounting for CST sparing, and complement person-level predictions.
format Online
Article
Text
id pubmed-9911610
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-99116102023-02-11 Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections Balbinot, Gustavo Li, Guijin Kalsi-Ryan, Sukhvinder Abel, Rainer Maier, Doris Kalke, Yorck-Bernhard Weidner, Norbert Rupp, Rüdiger Schubert, Martin Curt, Armin Zariffa, Jose Nat Commun Article Cervical spinal cord injury (SCI) causes extensive impairments for individuals which may include dextrous hand function. Although prior work has focused on the recovery at the person-level, the factors determining the recovery of individual muscles are poorly understood. Here, we investigate the muscle-specific recovery after cervical spinal cord injury in a retrospective analysis of 748 individuals from the European Multicenter Study about Spinal Cord Injury (NCT01571531). We show associations between corticospinal tract (CST) sparing and upper extremity recovery in SCI, which improves the prediction of hand muscle strength recovery. Our findings suggest that assessment strategies for muscle-specific motor recovery in acute spinal cord injury are improved by accounting for CST sparing, and complement person-level predictions. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9911610/ /pubmed/36759606 http://dx.doi.org/10.1038/s41467-023-36390-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Balbinot, Gustavo
Li, Guijin
Kalsi-Ryan, Sukhvinder
Abel, Rainer
Maier, Doris
Kalke, Yorck-Bernhard
Weidner, Norbert
Rupp, Rüdiger
Schubert, Martin
Curt, Armin
Zariffa, Jose
Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
title Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
title_full Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
title_fullStr Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
title_full_unstemmed Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
title_short Segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
title_sort segmental motor recovery after cervical spinal cord injury relates to density and integrity of corticospinal tract projections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911610/
https://www.ncbi.nlm.nih.gov/pubmed/36759606
http://dx.doi.org/10.1038/s41467-023-36390-7
work_keys_str_mv AT balbinotgustavo segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT liguijin segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT kalsiryansukhvinder segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT abelrainer segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT maierdoris segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT kalkeyorckbernhard segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT weidnernorbert segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT rupprudiger segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT schubertmartin segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT curtarmin segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections
AT zariffajose segmentalmotorrecoveryaftercervicalspinalcordinjuryrelatestodensityandintegrityofcorticospinaltractprojections

Ejemplares similares