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High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy

Neoadjuvant chemotherapy (NCT) has significantly improved the overall survival of patients with operable non‐small cell lung cancer (NSCLC). Chemotherapy can remodel the tumor immune microenvironment (TIME) and has an important influence on antitumor immunity. For patients who underwent surgery for...

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Autores principales: Jia, Wenxiao, Guo, Hongbo, Wang, Min, Li, Ji, Yu, Jinming, Zhu, Hui, Wu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911612/
https://www.ncbi.nlm.nih.gov/pubmed/36789099
http://dx.doi.org/10.1002/mco2.213
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author Jia, Wenxiao
Guo, Hongbo
Wang, Min
Li, Ji
Yu, Jinming
Zhu, Hui
Wu, Gang
author_facet Jia, Wenxiao
Guo, Hongbo
Wang, Min
Li, Ji
Yu, Jinming
Zhu, Hui
Wu, Gang
author_sort Jia, Wenxiao
collection PubMed
description Neoadjuvant chemotherapy (NCT) has significantly improved the overall survival of patients with operable non‐small cell lung cancer (NSCLC). Chemotherapy can remodel the tumor immune microenvironment (TIME) and has an important influence on antitumor immunity. For patients who underwent surgery for resected NSCLC following NCT (NCT‐NSCLC), a prognostic value comparison between naïve and post‐chemotherapy TIME is absent. We enrolled 89 patients with NCT‐NSCLC in this study; the tumor‐infiltrating lymphocyte (TIL), CD4+TIL, and CD8+TIL levels in naïve and post‐chemotherapy tumor tissues were detected using immunohistochemistry staining and divided into high and low groups. Kaplan–Meier analysis revealed that major pathology response, pathological tumor, node, and metastasis stage post‐NCT (ypTNM), high post‐chemotherapy TIL, high post‐chemotherapy CD8+TIL, low naïve CD4+TIL, low naïve CD4+/CD8+TIL ratio, and increased CD4+TIL levels post‐chemotherapy were favorable prognostic factors in patients with NCT‐NSCLC. Multivariate Cox analysis found that ypTNM, high post‐chemotherapy TIL, and increased CD4+TIL levels post‐chemotherapy were independent prognostic factors in patients with NCT‐NSCLC. These results indicate that a TIME remodeled by chemotherapy plays an important role in antitumor immunity and has a better prognostic value than the naïve TIME.
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spelling pubmed-99116122023-02-13 High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy Jia, Wenxiao Guo, Hongbo Wang, Min Li, Ji Yu, Jinming Zhu, Hui Wu, Gang MedComm (2020) Original Articles Neoadjuvant chemotherapy (NCT) has significantly improved the overall survival of patients with operable non‐small cell lung cancer (NSCLC). Chemotherapy can remodel the tumor immune microenvironment (TIME) and has an important influence on antitumor immunity. For patients who underwent surgery for resected NSCLC following NCT (NCT‐NSCLC), a prognostic value comparison between naïve and post‐chemotherapy TIME is absent. We enrolled 89 patients with NCT‐NSCLC in this study; the tumor‐infiltrating lymphocyte (TIL), CD4+TIL, and CD8+TIL levels in naïve and post‐chemotherapy tumor tissues were detected using immunohistochemistry staining and divided into high and low groups. Kaplan–Meier analysis revealed that major pathology response, pathological tumor, node, and metastasis stage post‐NCT (ypTNM), high post‐chemotherapy TIL, high post‐chemotherapy CD8+TIL, low naïve CD4+TIL, low naïve CD4+/CD8+TIL ratio, and increased CD4+TIL levels post‐chemotherapy were favorable prognostic factors in patients with NCT‐NSCLC. Multivariate Cox analysis found that ypTNM, high post‐chemotherapy TIL, and increased CD4+TIL levels post‐chemotherapy were independent prognostic factors in patients with NCT‐NSCLC. These results indicate that a TIME remodeled by chemotherapy plays an important role in antitumor immunity and has a better prognostic value than the naïve TIME. John Wiley and Sons Inc. 2023-02-09 /pmc/articles/PMC9911612/ /pubmed/36789099 http://dx.doi.org/10.1002/mco2.213 Text en © 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Jia, Wenxiao
Guo, Hongbo
Wang, Min
Li, Ji
Yu, Jinming
Zhu, Hui
Wu, Gang
High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy
title High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy
title_full High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy
title_fullStr High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy
title_full_unstemmed High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy
title_short High post‐chemotherapy TIL and increased CD4+TIL are independent prognostic factors of surgically resected NSCLC following neoadjuvant chemotherapy
title_sort high post‐chemotherapy til and increased cd4+til are independent prognostic factors of surgically resected nsclc following neoadjuvant chemotherapy
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911612/
https://www.ncbi.nlm.nih.gov/pubmed/36789099
http://dx.doi.org/10.1002/mco2.213
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