Adipocyte-derived extracellular vesicles increase insulin secretion through transport of insulinotropic protein cargo

Adipocyte-derived extracellular vesicles (AdEVs) are membranous nanoparticles that convey communication from adipose tissue to other organs. Here, to delineate their role as messengers with glucoregulatory nature, we paired fluorescence AdEV-tracing and SILAC-labeling with (phospho)proteomics, and r...

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Detalles Bibliográficos
Autores principales: Kulaj, Konxhe, Harger, Alexandra, Bauer, Michaela, Caliskan, Özüm S., Gupta, Tilak Kumar, Chiang, Dapi Menglin, Milbank, Edward, Reber, Josefine, Karlas, Angelos, Kotzbeck, Petra, Sailer, David N., Volta, Francesco, Lutter, Dominik, Prakash, Sneha, Merl-Pham, Juliane, Ntziachristos, Vasilis, Hauner, Hans, Pfaffl, Michael W., Tschöp, Matthias H., Müller, Timo D., Hauck, Stefanie M., Engel, Benjamin D., Gerdes, Jantje M., Pfluger, Paul T., Krahmer, Natalie, Stemmer, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911726/
https://www.ncbi.nlm.nih.gov/pubmed/36759608
http://dx.doi.org/10.1038/s41467-023-36148-1

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