Somatostatin slows Aβ plaque deposition in aged APP(NL-F/NL-F) mice by blocking Aβ aggregation

The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s disease (AD). Missing have been in vivo data in a relevant Aβ amyloidosis model. Here we crossed App(NL-F/NL-F) mice with Sst-deficient mice to assess if...

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Detalles Bibliográficos
Autores principales: Williams, Declan, Yan, Bei Qi, Wang, Hansen, Negm, Logine, Sackmann, Christopher, Verkuyl, Claire, Rezai-Stevens, Vanessa, Eid, Shehab, Vediya, Nimit, Sato, Christine, Watts, Joel C., Wille, Holger, Schmitt-Ulms, Gerold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911728/
https://www.ncbi.nlm.nih.gov/pubmed/36759538
http://dx.doi.org/10.1038/s41598-023-29559-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911728/
https://www.ncbi.nlm.nih.gov/pubmed/36759538
http://dx.doi.org/10.1038/s41598-023-29559-z

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