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A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners

Dyslipidemia is one of the known risk factors for cardiovascular disease, and its prevalence is increasing worldwide. At present, the study of dyslipidemia has gradually shifted from simple environmental or genetic factors to environment-gene interactions. In order to further explore the etiology an...

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Autores principales: Yang, Yongzhong, Zheng, Ziwei, Chen, Yuanyu, Wang, Xuelin, Wang, Hui, Si, Zhikang, Meng, Rui, Wu, Jianhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911731/
https://www.ncbi.nlm.nih.gov/pubmed/36759651
http://dx.doi.org/10.1038/s41598-023-29491-2
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author Yang, Yongzhong
Zheng, Ziwei
Chen, Yuanyu
Wang, Xuelin
Wang, Hui
Si, Zhikang
Meng, Rui
Wu, Jianhui
author_facet Yang, Yongzhong
Zheng, Ziwei
Chen, Yuanyu
Wang, Xuelin
Wang, Hui
Si, Zhikang
Meng, Rui
Wu, Jianhui
author_sort Yang, Yongzhong
collection PubMed
description Dyslipidemia is one of the known risk factors for cardiovascular disease, and its prevalence is increasing worldwide. At present, the study of dyslipidemia has gradually shifted from simple environmental or genetic factors to environment-gene interactions. In order to further explore the etiology and mechanism of dyslipidemia, we used occupational stress(OS) and LYPLAL1, APOC3 and SOD2 gene as research variables to explore their association with dyslipidemia.Here we used a case-control study to include Han workers from a coal mining enterprise in China to determine the association between study variables and dyslipidemia. Monofactor analysis showed that smoking, drinking, physical activity level, DASH diet score, sleep quality, BMI, hypertension, hyperuricemia, shift work, OS were significantly different between the two groups (P < 0.05). In the APOC3 rs2854116 dominant model, patients with CT/CC genotype had a higher risk of dyslipidemia than those with TT genotype. In SOD2 rs4880 recessive model, patients with GG genotype had a lower risk of dyslipidemia than those with AA/AG genotype, and the difference was statistically significant. We found that rs12137855 and OS, rs2854116 and OS, rs4880 and OS had joint effects, but no interaction based on the multiplication and addition model was found (P(interaction) > 0.05). GMDR model showed that the rs12137855-rs2854116-rs4880-OS four-factor model had the highest cross-validation consistency and training-validation accuracy (P < 0.05), suggesting that there was a high-order interaction between them associated with dyslipidemia. We found that dyslipidemia in coal miners was related to OS and genetic factors. Through this study, we revealed the dual regulation of environmental factors and genetic factors on dyslipidemia. At the same time, this study provides clues for understanding the etiology and mechanism of dyslipidemia.
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spelling pubmed-99117312023-02-11 A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners Yang, Yongzhong Zheng, Ziwei Chen, Yuanyu Wang, Xuelin Wang, Hui Si, Zhikang Meng, Rui Wu, Jianhui Sci Rep Article Dyslipidemia is one of the known risk factors for cardiovascular disease, and its prevalence is increasing worldwide. At present, the study of dyslipidemia has gradually shifted from simple environmental or genetic factors to environment-gene interactions. In order to further explore the etiology and mechanism of dyslipidemia, we used occupational stress(OS) and LYPLAL1, APOC3 and SOD2 gene as research variables to explore their association with dyslipidemia.Here we used a case-control study to include Han workers from a coal mining enterprise in China to determine the association between study variables and dyslipidemia. Monofactor analysis showed that smoking, drinking, physical activity level, DASH diet score, sleep quality, BMI, hypertension, hyperuricemia, shift work, OS were significantly different between the two groups (P < 0.05). In the APOC3 rs2854116 dominant model, patients with CT/CC genotype had a higher risk of dyslipidemia than those with TT genotype. In SOD2 rs4880 recessive model, patients with GG genotype had a lower risk of dyslipidemia than those with AA/AG genotype, and the difference was statistically significant. We found that rs12137855 and OS, rs2854116 and OS, rs4880 and OS had joint effects, but no interaction based on the multiplication and addition model was found (P(interaction) > 0.05). GMDR model showed that the rs12137855-rs2854116-rs4880-OS four-factor model had the highest cross-validation consistency and training-validation accuracy (P < 0.05), suggesting that there was a high-order interaction between them associated with dyslipidemia. We found that dyslipidemia in coal miners was related to OS and genetic factors. Through this study, we revealed the dual regulation of environmental factors and genetic factors on dyslipidemia. At the same time, this study provides clues for understanding the etiology and mechanism of dyslipidemia. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9911731/ /pubmed/36759651 http://dx.doi.org/10.1038/s41598-023-29491-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yang, Yongzhong
Zheng, Ziwei
Chen, Yuanyu
Wang, Xuelin
Wang, Hui
Si, Zhikang
Meng, Rui
Wu, Jianhui
A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
title A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
title_full A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
title_fullStr A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
title_full_unstemmed A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
title_short A case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
title_sort case control study on the relationship between occupational stress and genetic polymorphism and dyslipidemia in coal miners
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911731/
https://www.ncbi.nlm.nih.gov/pubmed/36759651
http://dx.doi.org/10.1038/s41598-023-29491-2
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