Splicing factor SRSF1 deficiency in the liver triggers NASH-like pathology and cell death

Regulation of RNA processing contributes profoundly to tissue development and physiology. Here, we report that serine-arginine-rich splicing factor 1 (SRSF1) is essential for hepatocyte function and survival. Although SRSF1 is mainly known for its many roles in mRNA metabolism, it is also crucial fo...

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Detalles Bibliográficos
Autores principales: Arif, Waqar, Mathur, Bhoomika, Saikali, Michael F., Chembazhi, Ullas V., Toohill, Katelyn, Song, You Jin, Hao, Qinyu, Karimi, Saman, Blue, Steven M., Yee, Brian A., Van Nostrand, Eric L., Bangru, Sushant, Guzman, Grace, Yeo, Gene W., Prasanth, Kannanganattu V., Anakk, Sayeepriyadarshini, Cummins, Carolyn L., Kalsotra, Auinash
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911759/
https://www.ncbi.nlm.nih.gov/pubmed/36759613
http://dx.doi.org/10.1038/s41467-023-35932-3

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