Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics

Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulat...

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Autores principales: Cen, Yinghuan, Chen, Letian, Liu, Zihao, Lin, Qun, Fang, Xiaolin, Yao, Herui, Gong, Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911762/
https://www.ncbi.nlm.nih.gov/pubmed/36759501
http://dx.doi.org/10.1038/s41420-023-01352-x
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author Cen, Yinghuan
Chen, Letian
Liu, Zihao
Lin, Qun
Fang, Xiaolin
Yao, Herui
Gong, Chang
author_facet Cen, Yinghuan
Chen, Letian
Liu, Zihao
Lin, Qun
Fang, Xiaolin
Yao, Herui
Gong, Chang
author_sort Cen, Yinghuan
collection PubMed
description Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer.
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spelling pubmed-99117622023-02-11 Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics Cen, Yinghuan Chen, Letian Liu, Zihao Lin, Qun Fang, Xiaolin Yao, Herui Gong, Chang Cell Death Discov Review Article Therapy resistance remains a huge challenge for current breast cancer treatments. Exploring molecular mechanisms of therapy resistance might provide therapeutic targets for patients with advanced breast cancer and improve their prognosis. RNA-binding proteins (RBPs) play an important role in regulating therapy resistance. Here we summarize the functions of RBPs, highlight their tremendously important roles in regulating therapy sensitivity and resistance and we also reveal current therapeutic approaches reversing abnormal functions of RBPs in breast cancer. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9911762/ /pubmed/36759501 http://dx.doi.org/10.1038/s41420-023-01352-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Cen, Yinghuan
Chen, Letian
Liu, Zihao
Lin, Qun
Fang, Xiaolin
Yao, Herui
Gong, Chang
Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
title Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
title_full Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
title_fullStr Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
title_full_unstemmed Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
title_short Novel roles of RNA-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
title_sort novel roles of rna-binding proteins in drug resistance of breast cancer: from molecular biology to targeting therapeutics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911762/
https://www.ncbi.nlm.nih.gov/pubmed/36759501
http://dx.doi.org/10.1038/s41420-023-01352-x
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