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Regulatory T cells (Tregs) in liver fibrosis
The ability of the human liver to both synthesize extracellular matrix(ECM), as well as regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver injury stimulates fibrogenesis in response to the imbalance between ECM accumulation and fibrosis resolution. Liver disease...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911787/ https://www.ncbi.nlm.nih.gov/pubmed/36759593 http://dx.doi.org/10.1038/s41420-023-01347-8 |
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author | Wu, Ke-jia Qian, Qu-fei Zhou, Jin-ren Sun, Dong-lin Duan, Yun-fei Zhu, Xi Sartorius, Kurt Lu, Yun-jie |
author_facet | Wu, Ke-jia Qian, Qu-fei Zhou, Jin-ren Sun, Dong-lin Duan, Yun-fei Zhu, Xi Sartorius, Kurt Lu, Yun-jie |
author_sort | Wu, Ke-jia |
collection | PubMed |
description | The ability of the human liver to both synthesize extracellular matrix(ECM), as well as regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver injury stimulates fibrogenesis in response to the imbalance between ECM accumulation and fibrosis resolution. Liver disease that induces fibrogenesis is associated with multiple risk factors like hepatitis infection, schistosomiasis, alcohol, certain drugs, toxicants and emerging aetiology like diabetes and obesity. The activation of hepatic stellate cells (HSCs), whose function is to generate and accumulate ECM, is a pivotal event in liver fibrosis. Simultaneously, HSCs selectively promote regulatory T-cells (Tregs) in an interleukin-2–dependent pattern that displays a dual relationship. On the one hand, Tregs can protect HSCs from NK cell attack, while on the other hand, they demonstrate an inhibitory effect on HSCs. This paper reviews the dual role of Tregs in liver fibrogenesis which includes its promotion of immunosuppression, as well as its activation of fibrosis. In particular, the balance between Tregs and the Th17 cell population, which produce interleukin (IL)-17 and IL-22, is explored to demonstrate their key role in maintaining homoeostasis and immunoregulation. The contradictory roles of Tregs in liver fibrosis in different immune microenvironments and molecular pathways need to be better understood if they are to be deployed to manage this disease. |
format | Online Article Text |
id | pubmed-9911787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99117872023-02-11 Regulatory T cells (Tregs) in liver fibrosis Wu, Ke-jia Qian, Qu-fei Zhou, Jin-ren Sun, Dong-lin Duan, Yun-fei Zhu, Xi Sartorius, Kurt Lu, Yun-jie Cell Death Discov Review Article The ability of the human liver to both synthesize extracellular matrix(ECM), as well as regulate fibrogenesis, are integral functions to maintaining homoeostasis. Chronic liver injury stimulates fibrogenesis in response to the imbalance between ECM accumulation and fibrosis resolution. Liver disease that induces fibrogenesis is associated with multiple risk factors like hepatitis infection, schistosomiasis, alcohol, certain drugs, toxicants and emerging aetiology like diabetes and obesity. The activation of hepatic stellate cells (HSCs), whose function is to generate and accumulate ECM, is a pivotal event in liver fibrosis. Simultaneously, HSCs selectively promote regulatory T-cells (Tregs) in an interleukin-2–dependent pattern that displays a dual relationship. On the one hand, Tregs can protect HSCs from NK cell attack, while on the other hand, they demonstrate an inhibitory effect on HSCs. This paper reviews the dual role of Tregs in liver fibrogenesis which includes its promotion of immunosuppression, as well as its activation of fibrosis. In particular, the balance between Tregs and the Th17 cell population, which produce interleukin (IL)-17 and IL-22, is explored to demonstrate their key role in maintaining homoeostasis and immunoregulation. The contradictory roles of Tregs in liver fibrosis in different immune microenvironments and molecular pathways need to be better understood if they are to be deployed to manage this disease. Nature Publishing Group UK 2023-02-09 /pmc/articles/PMC9911787/ /pubmed/36759593 http://dx.doi.org/10.1038/s41420-023-01347-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Wu, Ke-jia Qian, Qu-fei Zhou, Jin-ren Sun, Dong-lin Duan, Yun-fei Zhu, Xi Sartorius, Kurt Lu, Yun-jie Regulatory T cells (Tregs) in liver fibrosis |
title | Regulatory T cells (Tregs) in liver fibrosis |
title_full | Regulatory T cells (Tregs) in liver fibrosis |
title_fullStr | Regulatory T cells (Tregs) in liver fibrosis |
title_full_unstemmed | Regulatory T cells (Tregs) in liver fibrosis |
title_short | Regulatory T cells (Tregs) in liver fibrosis |
title_sort | regulatory t cells (tregs) in liver fibrosis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911787/ https://www.ncbi.nlm.nih.gov/pubmed/36759593 http://dx.doi.org/10.1038/s41420-023-01347-8 |
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