Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

Alterations in energy metabolism are associated with depression. However, the role of glycolysis in the pathogenesis of depression and the underlying molecular mechanisms remain unexplored. Through an unbiased proteomic screen coupled with biochemical verifications, we show that the levels of glycol...

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Detalles Bibliográficos
Autores principales: Yao, Shan, Xu, Min-Dong, Wang, Ying, Zhao, Shen-Ting, Wang, Jin, Chen, Gui-Fu, Chen, Wen-Bing, Liu, Jian, Huang, Guo-Bin, Sun, Wen-Juan, Zhang, Yan-Yan, Hou, Huan-Li, Li, Lei, Sun, Xiang-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911790/
https://www.ncbi.nlm.nih.gov/pubmed/36759610
http://dx.doi.org/10.1038/s41467-023-36209-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911790/
https://www.ncbi.nlm.nih.gov/pubmed/36759610
http://dx.doi.org/10.1038/s41467-023-36209-5

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