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Astrocytic lactate dehydrogenase A regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice
Alterations in energy metabolism are associated with depression. However, the role of glycolysis in the pathogenesis of depression and the underlying molecular mechanisms remain unexplored. Through an unbiased proteomic screen coupled with biochemical verifications, we show that the levels of glycol...
Autores principales: | Yao, Shan, Xu, Min-Dong, Wang, Ying, Zhao, Shen-Ting, Wang, Jin, Chen, Gui-Fu, Chen, Wen-Bing, Liu, Jian, Huang, Guo-Bin, Sun, Wen-Juan, Zhang, Yan-Yan, Hou, Huan-Li, Li, Lei, Sun, Xiang-Dong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9911790/ https://www.ncbi.nlm.nih.gov/pubmed/36759610 http://dx.doi.org/10.1038/s41467-023-36209-5 |
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