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Atypical functions of xenobiotic receptors in lipid and glucose metabolism
Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics. Emerging evidence suggests that “xenobiotic receptors” al...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
De Gruyter
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912049/ https://www.ncbi.nlm.nih.gov/pubmed/36785576 http://dx.doi.org/10.1515/mr-2022-0032 |
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author | Wang, Jingyuan Lu, Peipei Xie, Wen |
author_facet | Wang, Jingyuan Lu, Peipei Xie, Wen |
author_sort | Wang, Jingyuan |
collection | PubMed |
description | Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics. Emerging evidence suggests that “xenobiotic receptors” also have diverse endobiotic functions, including their effects on lipid metabolism and energy metabolism. Dyslipidemia is a major risk factor for cardiovascular disease, diabetes, obesity, metabolic syndrome, stroke, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH). Understanding the molecular mechanism by which transcriptional factors, including the xenobiotic receptors, regulate lipid homeostasis will help to develop preventive and therapeutic approaches. This review describes recent advances in our understanding the atypical roles of three xenobiotic receptors: aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), and constitutive androstane receptor (CAR), in metabolic disorders, with a particular focus on their effects on lipid and glucose metabolism. Collectively, the literatures suggest the potential values of AhR, PXR and CAR as therapeutic targets for the treatment of NAFLD, NASH, obesity and diabetes, and cardiovascular diseases. |
format | Online Article Text |
id | pubmed-9912049 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | De Gruyter |
record_format | MEDLINE/PubMed |
spelling | pubmed-99120492023-02-11 Atypical functions of xenobiotic receptors in lipid and glucose metabolism Wang, Jingyuan Lu, Peipei Xie, Wen Med Rev (Berl) Review Xenobiotic receptors are traditionally defined as xenobiotic chemical-sensing receptors, the activation of which transcriptionally regulates the expression of enzymes and transporters involved in the metabolism and disposition of xenobiotics. Emerging evidence suggests that “xenobiotic receptors” also have diverse endobiotic functions, including their effects on lipid metabolism and energy metabolism. Dyslipidemia is a major risk factor for cardiovascular disease, diabetes, obesity, metabolic syndrome, stroke, nonalcoholic fatty liver disease (NAFLD), and nonalcoholic steatohepatitis (NASH). Understanding the molecular mechanism by which transcriptional factors, including the xenobiotic receptors, regulate lipid homeostasis will help to develop preventive and therapeutic approaches. This review describes recent advances in our understanding the atypical roles of three xenobiotic receptors: aryl hydrocarbon receptor (AhR), pregnane X receptor (PXR), and constitutive androstane receptor (CAR), in metabolic disorders, with a particular focus on their effects on lipid and glucose metabolism. Collectively, the literatures suggest the potential values of AhR, PXR and CAR as therapeutic targets for the treatment of NAFLD, NASH, obesity and diabetes, and cardiovascular diseases. De Gruyter 2022-11-30 /pmc/articles/PMC9912049/ /pubmed/36785576 http://dx.doi.org/10.1515/mr-2022-0032 Text en © 2022 the author(s), published by De Gruyter, Berlin/Boston https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |
spellingShingle | Review Wang, Jingyuan Lu, Peipei Xie, Wen Atypical functions of xenobiotic receptors in lipid and glucose metabolism |
title | Atypical functions of xenobiotic receptors in lipid and glucose metabolism |
title_full | Atypical functions of xenobiotic receptors in lipid and glucose metabolism |
title_fullStr | Atypical functions of xenobiotic receptors in lipid and glucose metabolism |
title_full_unstemmed | Atypical functions of xenobiotic receptors in lipid and glucose metabolism |
title_short | Atypical functions of xenobiotic receptors in lipid and glucose metabolism |
title_sort | atypical functions of xenobiotic receptors in lipid and glucose metabolism |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912049/ https://www.ncbi.nlm.nih.gov/pubmed/36785576 http://dx.doi.org/10.1515/mr-2022-0032 |
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